ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
A novel member of the Ig superfamily, turtle, is a CNS-specific protein required for coordinated motor control.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 56 citations in OpenAlex.
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- Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement.Journal of cell science · 2021Article
- First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory.PloS one · 2021Article
- A Single MicroRNA-Hox Gene Module Controls Equivalent Movements in Biomechanically Distinct Forms of Drosophila.Current biology : CB · 2019Article
- Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila.Developmental biology · 2019Article
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling.Development (Cambridge, England) · 2017Article
- Turtle interacts with borderless in regulating glial extension and axon ensheathment.Molecular brain · 2017Article
- Transcriptomic analysis of instinctive and learned reward-related behaviors in honey bees.The Journal of experimental biology · 2016Article
- Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models.Human molecular genetics · 2016Article
- Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model.Disease models & mechanisms · 2014Article
- Patterns of positive selection in seven ant genomes.Molecular biology and evolution · 2014Article
- Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- IGSF9 family proteins.Neurochemical research · 2013Review
- RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.Human molecular genetics · 2013Article
- Control of directional change after mechanical stimulation in Drosophila.Molecular brain · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We describe here the cloning and functional characterization of a neural-specific novel member of the Ig superfamily, turtle (tutl), with a structure of five Ig C2-type domains, two fibronectin type III domains, and one transmembrane region. Alternative splicing of the tutl gene produces at least four Tutl isoforms, including two transmembrane proteins and two secreted proteins, with primary structures closely related to a human brain protein (KIAA1355), the Deleted in Colorectal Cancer/Neogenin/Frazzled receptor family, and the Roundabout/Dutt1 receptor family. An allelic series of tutl gene mutations resulted in recessive lethality to semilethality, indicating that the gene is essential. In contrast to other family members, tutl does not play a detectable role in axon pathfinding or nervous system morphogenesis. Likewise, basal synaptic transmission and locomotory movement are unaffected. However, tutl mutations cause striking movement defects exhibited in specific types of highly coordinated behavior. Specifically, tutl mutants display an abnormal response to tactile stimulation, the inability to regain an upright position from an inverted position (hence, "turtle"), and the inability to fly in adulthood. These phenotypes demonstrate that tutl plays an essential role in establishing a nervous system capable of executing coordinated motor output in complex behaviors.
Indexed as
Identifiers
11312296PMC6762567W2107885885What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.