ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
How protein kinase C activation protects nerve cells from oxidative stress-induced cell death.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 214 citations in OpenAlex.
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- PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer's Disease Hippocampus.Frontiers in aging neuroscience · 2022Article
- PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis.Nature cell biology · 2022Article
- The Mechanisms Underlying the Protective Action of Selenium Nanoparticles against Ischemia/Reoxygenation Are Mediated by the Activation of the CaInternational journal of molecular sciences · 2021Article
- Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis.Cell death & disease · 2021Article
- Neuroprotective Properties of Green Tea (Molecules (Basel, Switzerland) · 2020Review
- Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia.Biomolecules · 2020Article
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- The Antidepressant-Like Effect of Lactate in an Animal Model of Menopausal Depression.Biomedicines · 2018Article
- Chlorogenic Acid Prevents AMPA-Mediated Excitotoxicity in Optic Nerve Oligodendrocytes Through a PKC and Caspase-Dependent Pathways.Neurotoxicity research · 2018Article
- Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2018Review
- Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.Frontiers in neuroscience · 2018Review
- PKC in developmental hypothyroid rat brain.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Review
- Lead exposure disrupts global DNA methylation in human embryonic stem cells and alters their neuronal differentiation.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.Hepatology (Baltimore, Md.) · 2014Article
- Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease.Neuromolecular medicine · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Oxidative stress is implicated in the nerve cell death that occurs in a variety of neurological disorders, and the loss of protein kinase C (PKC) activity has been coupled to the severity of the damage. The functional relationship between stress, PKC, and cell death is, however, unknown. Using an immortalized hippocampal cell line that is particularly sensitive to oxidative stress, I show that activation of PKC by the phorbol ester tetradecanoylphorbol acetate (TPA) inhibits cell death via the stimulation of a complex protein phosphorylation pathway. TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta. Inhibition of either ERK or JNK activation blocks TPA-mediated protection, whereas p38 MAPK and PKCdelta inhibitors block stress-induced nerve cell death. Both p38 MAPK inactivation and JNK activation appear to be downstream of ERK because an agent that blocks ERK activation also blocks the modulation of these other MAP kinase family members by TPA treatment. Thus, the protection from oxidative stress afforded nerve cells by PKC activity requires the combined modulation of multiple enzyme pathways and suggests why the loss of PKC activity contributes to nerve cell death.
Indexed as
Identifiers
11312276PMC6762555W1486333767What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.