ArticleDevelopment (Cambridge, England)2001
even skipped is required to produce a trans-acting signal for larval neuroblast proliferation that can be mimicked by ecdysone.
Article in Development (Cambridge, England), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Non-autonomous regulation of neurogenesis by extrinsic cues: aOxford open neuroscience · 2022Review
- The proteoglycan Trol controls the architecture of the extracellular matrix and balances proliferation and differentiation of blood progenitors in the Drosophila lymph gland.Developmental biology · 2013Article
- Extracellular matrix and its receptors in Drosophila neural development.Developmental neurobiology · 2011Review
- Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan.Developmental cell · 2011Article
- The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts.BMC developmental biology · 2007Article
- Dissection of larval CNS in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2006Article
- Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries.Development (Cambridge, England) · 2001Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Development of a multicellular organism requires precise coordination of cell division and cell type determination. The selector homeoprotein Even skipped (Eve) plays a very specific role in determining cell identity in the Drosophila embryo, both during segmentation and in neuronal development. However, studies of gene expression in eve mutant embryos suggest that eve regulates the embryonic expression of the vast majority of genes. We present here genetic interaction and phenotypic analysis showing that eve functions in the trol pathway to regulate the onset of neuroblast division in the larval CNS. Surprisingly, Eve is not detected in the regulated neuroblasts, and culture experiments reveal that Eve is required in the body, not the CNS. Furthermore, the effect of an eve mutation can be rescued both in vivo and in culture by the hormone ecdysone. These results suggest that eve is required to produce a trans-acting factor that stimulates cell division in the larval brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.