ArticleAmerican journal of human genetics2001
Transmission/disequilibrium test meets measured haplotype analysis: family-based association analysis guided by evolution of haplotypes.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples.Biological psychiatry · 2006Pooled it
- Imputation without doing imputation: a new method for the detection of non-genotyped causal variants.Genetic epidemiology · 2014Article
- Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort.Journal of psychiatric research · 2013Article
- A sparse transmission disequilibrium test for haplotypes based on Bradley-Terry graphs.Human heredity · 2012Article
- Article
- Combining an evolution-guided clustering algorithm and haplotype-based LRT in family association studies.BMC genetics · 2011Article
- Using an uncertainty-coding matrix in Bayesian regression models for haplotype-specific risk detection in family association studies.PloS one · 2011Article
- A Bayesian hierarchical model for detecting haplotype-haplotype and haplotype-environment interactions in genetic association studies.Human heredity · 2011Article
- Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test.Human genetics · 2010Article
- A data-driven weighting scheme for family-based genome-wide association studies.European journal of human genetics : EJHG · 2010Article
- A novel approach for haplotype-based association analysis using family data.BMC bioinformatics · 2010Article
- The diverse applications of cladistic analysis of molecular evolution, with special reference to nested clade analysis.International journal of molecular sciences · 2010Review
- Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.Brain, behavior, and immunity · 2010Article
- SHARE: an adaptive algorithm to select the most informative set of SNPs for candidate genetic association.Biostatistics (Oxford, England) · 2009Article
- Structures and Assumptions: Strategies to Harness Gene × Gene and Gene × Environment Interactions in GWAS.Statistical science : a review journal of the Institute of Mathematical Statistics · 2009Article
- HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.Human heredity · 2008Review
- A multi-marker test based on family data in genome-wide association study.BMC genetics · 2007Article
- Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder.Genes, brain, and behavior · 2007Article
- Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows.American journal of human genetics · 2007Article
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3 authors.
Funding
Abstract
Family data teamed with the transmission/disequilibrium test (TDT), which simultaneously evaluates linkage and association, is a powerful means of detecting disease-liability alleles. To increase the information provided by the test, various researchers have proposed TDT-based methods for haplotype transmission. Haplotypes indeed produce more-definitive transmissions than do the alleles comprising them, and this tends to increase power. However, the larger number of haplotypes, relative to alleles at individual loci, tends to decrease power, because of the additional degrees of freedom required for the test. An optimal strategy would focus the test on particular haplotypes or groups of haplotypes. In this report we develop such an approach by combining the theory of TDT with that of measured haplotype analysis (MHA). MHA uses the evolutionary relationships among haplotypes to produce a limited set of hypothesis tests and to increase the interpretability of these tests. The theory of our approach, called the "evolutionary tree" (ET)-TDT, is developed for two cases: when haplotype transmission is certain and when it is not. Simulations show the ET-TDT can be more powerful than other proposed methods under reasonable conditions. More importantly, our results show that, when multiple polymorphisms are found within the gene, the ET-TDT can be useful for determining which polymorphisms affect liability.
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