ArticleAmerican journal of human genetics2001
Transformation of sib-pair values for the Haseman-Elston method.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Comparison of Haseman-Elston regression analyses using single, summary, and longitudinal measures of systolic blood pressure.BMC genetics · 2003Article
- Regression-based quantitative-trait-locus mapping in the 21st century.American journal of human genetics · 2002Article
- A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size.American journal of human genetics · 2002Article
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Authors and funding
5 authors.
Funding
Abstract
The squared sib-pair phenotype difference (SQD) has been used as a dependent variable in the Haseman-Elston (H-E) regression quantitative-trait locus (QTL) linkage method, but it has been shown that the SQD does not make full use of linkage information. In this study, we examine the efficiency of SQD in H-E regression compared to other proposed functions of the sib-pair phenotypes. A new function of sib-pair phenotypes, the product of pair values corrected with family mean (PCF), is shown to have desirable properties in many realistic situations. Consistent results were obtained using a combination of large-sample analytic approximations, simulation, and analyses of quantitative-trait data from Genetic Analysis Workshop 10. The advantages of PCF are further improved in the presence of family-specific effects arising from environmental factors or when additional QTLs influence the trait. All of the phenotype functions are incorporated in our new, freely available linkage-mapping program MULTIGENE 1.0 for the PC environment.
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