ArticleAmerican journal of human genetics2001
Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 179 citations in OpenAlex.
- Putative linkage signals identified for breast cancer in African American families.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Trial
- The genetic epidemiology of prostate cancer and its clinical implications.Nature reviews. Urology · 2014Review
- Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer.Pharmacogenomics and personalized medicine · 2014Review
- Prostate cancer susceptibility genes on 8p21-23 in a Dutch population.Prostate cancer and prostatic diseases · 2013Article
- The null distribution of likelihood-ratio statistics in the conditional-logistic linkage model.Frontiers in genetics · 2013Article
- Inherited susceptibility for aggressive prostate cancer.Asian journal of andrology · 2012Review
- A method to detect single-nucleotide polymorphisms accounting for a linkage signal using covariate-based affected relative pair linkage analysis.BMC proceedings · 2011Article
- Article
- Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study.Cancer genetics · 2011Article
- Some capabilities for model-based and model-free linkage analysis using the program package S.A.G.E. (Statistical Analysis for Genetic Epidemiology).Human heredity · 2011Article
- Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs.BMC genetics · 2010Article
- Results from a prostate cancer admixture mapping study in African-American men.Human genetics · 2009Article
- Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Article
- Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage.Human molecular genetics · 2009Article
- Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease.European journal of human genetics : EJHG · 2009Article
- Finding genes underlying human disease.Clinical genetics · 2009Review
- Prostate cancer susceptibility loci: finding the genes.Advances in experimental medicine and biology · 2008Review
- Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes.Human genetics · 2007Article
- Genetic linkage analysis of sarcoidosis phenotypes: the sarcoidosis genetic analysis (SAGA) study.Genes and immunity · 2007Article
- Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates.Molecular psychiatry · 2007Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
As with many complex genetic diseases, genome scans for prostate cancer have given conflicting results, often failing to provide replication of previous findings. One factor contributing to the lack of consistency across studies is locus heterogeneity, which can weaken or even eliminate evidence for linkage that is present only in a subset of families. Currently, most analyses either fail to account for locus heterogeneity or attempt to account for it only by partitioning data sets into smaller and smaller portions. In the present study, we model locus heterogeneity among affected sib pairs with prostate cancer by including covariates in the linkage analysis that serve as surrogate measures of between-family linkage differences. The model is a modification of the Olson conditional logistic model for affected relative pairs. By including Gleason score, age at onset, male-to-male transmission, and/or number of affected first-degree family members as covariates, we detected linkage near three locations that were previously identified by linkage (1q24-25 [HPC1; LOD score 3.25, P=.00012], 1q42.2-43 [PCAP; LOD score 2.84, P=.0030], and 4q [LOD score 2.80, P=.00038]), near the androgen-receptor locus on Xq12-13 (AR; LOD score 3.06, P=.00053), and at five new locations (LOD score > 2.5). Without covariates, only a few weak-to-moderate linkage signals were found, none of which replicate findings of previous genome scans. We conclude that covariate-based linkage analysis greatly improves the likelihood that linked regions will be found by incorporation of information about heterogeneity within the sample.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.