ReviewHeart failure reviews2001
The role of interleukin-1 in the failing heart.
Review in Heart failure reviews, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 95 citations in OpenAlex.
- Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study.Journal of cardiovascular pharmacology · 2016Trial
- Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure.PloS one · 2012Trial
- Inflammation and the Heart: The Role of Traditional Factors.Cardiology research and practice · 2026Review
- Matrix metalloproteinase-9 as a messenger in the cross talk between obstructive sleep apnea and comorbid systemic hypertension, cardiac remodeling, and ischemic stroke: a literature review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Review
- Cardiac Fibroblasts and Myocardial Regeneration.Frontiers in bioengineering and biotechnology · 2021Review
- Review
- Role of cytokines and inflammation in heart function during health and disease.Heart failure reviews · 2018Review
- Intermediate filaments in cardiomyopathy.Biophysical reviews · 2018Review
- IFN-β Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation.Frontiers in pharmacology · 2018Article
- Intra-renal delivery of mesenchymal stem cells attenuates myocardial injury after reversal of hypertension in porcine renovascular disease.Stem cell research & therapy · 2015Article
- Article
- Anti-inflammatory peptides from cardiac progenitors ameliorate dysfunction after myocardial infarction.Journal of the American Heart Association · 2014Article
- Cardiac fibroblast in development and wound healing.Journal of molecular and cellular cardiology · 2014Review
- Matrix metalloproteinase-9: Many shades of function in cardiovascular disease.Physiology (Bethesda, Md.) · 2013Review
- Inflammatory activation: cardiac, renal, and cardio-renal interactions in patients with the cardiorenal syndrome.Heart failure reviews · 2012Review
- MicroRNA involvement in immune activation during heart failure.Cardiovascular drugs and therapy · 2011Review
- Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities.Heart failure reviews · 2011Review
- Origins of cardiac fibroblasts.Circulation research · 2010Review
- Cardiac fibroblast: the renaissance cell.Circulation research · 2009Review
- Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype.Journal of cardiac failure · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The prevalence of congestive heart failure and its continued poor prognosis despite presently available therapeutic options emphasize the importance of pursuing the observations suggesting an important role for an immunomodulatory approach to decompensated cardiac failure. Furthermore, there are several pieces of background information that suggest that cytokines like IL-1 may play a significant role in the pathogenesis of several forms of myocardial dysfunction. Although it seems clear that IL-1 is not acting alone under circumstances of myocardial injury, but in concert with other pro-inflammatory molecules and their effectors, we believe that continued investigations into the cytokine hypothesis will ultimately increase the understanding of how pro-inflammatory molecules influence myocardial function and how the modulation of such factors may improve the myocardial response to injury. The specific observations that emphasize the importance of pursuing a substantive role for IL-1 in this process are: (1) IL-1 is elevated in several cardiac disease states, (2) IL-1 is produced by myocardial cells themselves in response to injury, (3)The alterations in gene expression seen in response IL-1 resembles in many ways the phenotype of the failing heart, and (4) The co-localization of the IL-1 response with that of several previously described negative transcriptional regulators (making them potential targets for therapeutic manipulation).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.