ArticleProceedings of the National Academy of Sciences of the United States of America2001
Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Inhibition of MicroRNA-23b Attenuates Immunosuppression During Late Sepsis Through NIK, TRAF1, and XIAP.The Journal of infectious diseases · 2018Article
- FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Fas death receptor signalling: roles of Bid and XIAP.Cell death and differentiation · 2012Review
- Anti-apoptotic effect of hyperglycemia can allow survival of potentially autoreactive T cells.Cell death and differentiation · 2011Article
- IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.Nature reviews. Cancer · 2010Review
- Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization.The Journal of biological chemistry · 2010Article
- Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades.Current cancer drug targets · 2009Review
- Article
- Regulation of apoptosis by XIAP ubiquitin-ligase activity.Genes & development · 2008Article
- IAPs: what's in a name?Molecular cell · 2008Review
- Death pathways in T cell homeostasis and their role in autoimmune diabetes.The review of diabetic studies : RDS · 2006Article
- Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.Molecular and cellular biology · 2005Article
- Molecular pharmacodynamics in childhood leukemia.International journal of hematology · 2003Review
- Alterations in the apoptotic machinery and their potential role in anticancer drug resistance.Oncogene · 2003Review
- Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis.The Journal of experimental medicine · 2003Article
- Article
- Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes.BMC genomics · 2002Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The X-linked inhibitor of apoptosis (XIAP) and other members of the inhibitor of apoptosis (IAP) family can suppress apoptosis induced by a diverse variety of triggers. Functional studies done to date have focused on tissue culture models and adenovirus overexpression of XIAP and other IAP proteins. Here we report the phenotype of an engineered transgenic mouse overexpressing a human IAP, as well as assessing the long-term consequence of IAP overexpression. We document the relative protein expression levels of the endogenous mouse homologue to XIAP, mouse inhibitor of apoptosis (MIAP 3), within thymocyte and T cell subpopulations. The consequence of lymphoid-targeted overexpression of XIAP in transgenic mice suggests a physiological role for the endogenous protein, MIAP3. Xiap-transgenic mice accumulated thymocytes and/or T cells in primary and secondary lymphoid tissue, T cell maturation was perturbed, and transgenic thymocytes resisted a variety of apoptotic triggers both in vitro and in vivo. These observations imply a possible key function for the intrinsic cellular inhibitor XIAP in maintaining the homeostasis of the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.