ReviewMolecular microbiology2001
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
Review in Molecular microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 320 citations in OpenAlex.
- The Ti Plasmid-Encoded VirJ Functions as a Lysyl-Phosphatidylglycerol Hydrolase in Agrobacterium tumefaciens.Molecular microbiology · 2026Article
- Investigation and pathogenetic testing of Shewanella spp. positive diarrhea cases in Beijing, China.Scientific reports · 2025Article
- Review
- First Report and Characterization of a Plasmid-EncodedMicroorganisms · 2024Article
- Flagellar interference with plasmid uptake in biofilms: a joint experimental and modeling study.Applied and environmental microbiology · 2024Article
- Article
- Genomic insight into the integrative conjugative elements from ICEFrontiers in veterinary science · 2022Article
- The Distribution ofGenes · 2021Article
- Novel virulence factorWorld journal of gastroenterology · 2020Review
- Bacterial injection machines: Evolutionary diverse but functionally convergent.Cellular microbiology · 2020Article
- Co-dependent and Interdigitated: Dual Quorum Sensing Systems Regulate Conjugative Transfer of the Ti Plasmid and the At Megaplasmid inFrontiers in microbiology · 2020Article
- Novel Mobilizable Genomic Island GEI-D18A Mediates Conjugational Transfer of Antibiotic Resistance Genes in the Multidrug-Resistant StrainFrontiers in microbiology · 2020Article
- Immunoglobulin for Treating Bacterial Infections: One More Mechanism of Action.Antibodies (Basel, Switzerland) · 2019Review
- Trans-Kingdom Conjugation within Solid Media fromInternational journal of molecular sciences · 2019Article
- Global Regulator PhoP is Necessary for Motility, Biofilm Formation, Exoenzyme Production and Virulence ofGenes · 2019Article
- Comparative Genomic Analyses Reveal Core-Genome-Wide Genes Under Positive Selection and Major Regulatory Hubs in Outlier Strains ofFrontiers in microbiology · 2019Article
- Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system.Nature communications · 2018Article
- Strain-level genetic diversity ofPeerJ · 2018Article
- Demonstration that a Klebsiella pneumoniae subsp. pneumoniae isolated from an insect (Nezara viridula) harbors a plasmid-borne type IV secretion system.Current microbiology · 2017Article
- Conjugative Mating Assays for Sequence-specific Analysis of Transfer Proteins Involved in Bacterial Conjugation.Journal of visualized experiments : JoVE · 2017Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Bacterial conjugation systems are highly promiscuous macromolecular transfer systems that impact human health significantly. In clinical settings, conjugation is exceptionally problematic, leading to the rapid dissemination of antibiotic resistance genes and other virulence traits among bacterial populations. Recent work has shown that several pathogens of plants and mammals - Agrobacterium tumefaciens, Bordetella pertussis, Helicobacter pylori and Legionella pneumophila - have evolved secretion pathways ancestrally related to conjugation systems for the purpose of delivering effector molecules to eukaryotic target cells. Each of these systems exports distinct DNA or protein substrates to effect a myriad of changes in host cell physiology during infection. Collectively, secretion pathways ancestrally related to bacterial conjugation systems are now referred to as the type IV secretion family. The list of putative type IV family members is increasing rapidly, suggesting that macromolecular transfer by these systems is a widespread phenomenon in nature.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.