ArticleThe Journal of physiology2001
Unitary synaptic currents between lacunosum-moleculare interneurones and pyramidal cells in rat hippocampus.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 33 citations in OpenAlex.
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- Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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- Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit.Hippocampus · 2012Article
- Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons.PloS one · 2012Article
- The effect of neural noise on spike time precision in a detailed CA3 neuron model.Computational and mathematical methods in medicine · 2012Article
- Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.Nature neuroscience · 2010Article
- Gene therapy in epilepsy.Epilepsia · 2009Review
- Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.Journal of neurophysiology · 2009Article
- GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord.The Journal of physiology · 2008Article
- Electrical coupling between interneurons with different excitable properties in the stratum lacunosum-moleculare of the juvenile CA1 rat hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Synaptic interactions between pyramidal cells and interneurone subtypes during seizure-like activity in the rat hippocampus.The Journal of physiology · 2004Article
- Resonant synchronization in heterogeneous networks of inhibitory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission.The Journal of physiology · 2003Article
- Progesterone withdrawal reduces paired-pulse inhibition in rat hippocampus: dependence on GABA(A) receptor alpha4 subunit upregulation.Journal of neurophysiology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Unitary inhibitory postsynaptic currents (uIPSCs) were characterised between 23 synaptically coupled interneurones at the border of stratum radiatum and lacunosum-moleculare (LM) and CA1 pyramidal cells (PYR) using dual whole-cell recordings and morphological identification in rat hippocampal slices. 2. LM interneurones presented a morphology typical of stellate cells, with a fusiform soma as well as dendritic and axonal arborisations in stratum radiatum and lacunosum-moleculare. 3. Single spikes in interneurones triggered uIPSCs in pyramidal cells that were blocked by the GABA(A) antagonist bicuculline and mediated by a chloride conductance. The latency, rise time, duration and decay time constant of uIPSCs were a function of amplitude in all pairs, suggesting a homogeneity in the population sampled. 4. During paired pulse stimulation, individual LM-PYR connections exhibited facilitation or depression. The paired pulse ratio was inversely related to the amplitude of the first response. The transition from facilitation to depression occurred at 26 % of the maximal amplitude of the first uIPSC. Paired pulse depression was not modified by CGP 55845 and thus was GABA(B) receptor independent. 5. CGP 55845 failed to modify the amplitude of uIPSCs, suggesting an absence of tonic presynaptic GABA(B) inhibition at LM-PYR connections. 6. Increasing GABA release by repetitive activation of interneurones failed to induce GABA(B) IPSCs. With extracellular minimal stimulation, increasing stimulation intensity above threshold, or repetitive activation, evoked GABA(B) IPSCs, probably as a result of coactivation of several GABAergic fibres. 7. Thus, dendritic inhibition by LM interneurones involves GABA(A) uIPSCs with kinetics dependent on response amplitude and subject to GABA(B)-independent paired pulse plasticity.
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