ArticleThe Journal of physiology2001
Calcium influx-independent depression of transmitter release by 5-HT at lamprey spinal cord synapses.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Live Cell Light Sheet Imaging with Low- and High-Spatial-Coherence Detection Approaches Reveals Spatiotemporal Aspects of Neuronal Signaling.Journal of imaging · 2023Article
- Single Calcium Channel Nanodomains Drive Presynaptic Calcium Entry at Lamprey Reticulospinal Presynaptic Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Synaptic Integration of Subquantal Neurotransmission by Colocalized G Protein-Coupled Receptors in Presynaptic Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Gβγ SNARE Interactions and Their Behavioral Effects.Neurochemical research · 2019Review
- Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.Science signaling · 2019Article
- The expanding roles and mechanisms of G protein-mediated presynaptic inhibition.The Journal of biological chemistry · 2019Review
- A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.Frontiers in neural circuits · 2016Review
- Acute dissociation of lamprey reticulospinal axons to enable recording from the release face membrane of individual functional presynaptic terminals.Journal of visualized experiments : JoVE · 2014Article
- Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Differential regulation of synaptic transmission by pre- and postsynaptic SK channels in the spinal locomotor network.Journal of neurophysiology · 2013Article
- Role of presynaptic metabotropic glutamate receptors in the induction of long-term synaptic plasticity of vesicular release.Neuropharmacology · 2013Review
- Synaptic NMDA receptor-dependent Ca²⁺ entry drives membrane potential and Ca²⁺ oscillations in spinal ventral horn neurons.PloS one · 2013Article
- Presynaptic G-protein-coupled receptors dynamically modify vesicle fusion, synaptic cleft glutamate concentrations, and motor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Brain-machine interactions for assessing the dynamics of neural systems.Frontiers in neurorobotics · 2009Article
- Presynaptic G-protein-coupled receptors regulate synaptic cleft glutamate via transient vesicle fusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Location and function of vesicle clusters, active zones and Ca2+ channels in the lamprey presynaptic terminal.The Journal of physiology · 2005Article
- G protein {beta}{gamma} subunits mediate presynaptic inhibition of transmitter release from rat superior cervical ganglion neurones in culture.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The mechanisms by which 5-hydroxytryptamine (5-HT) depresses transmitter release from lamprey reticulospinal axons were investigated. These axons make glutamatergic synapses onto spinal ventral horn neurons. 5-HT reduces release at these synapses, yet the mechanisms remain unclear. 2. Excitatory postsynaptic currents (EPSCs) evoked by stimulation of reticulospinal axons were recorded in ventral horn neurons. 5-HT depressed the EPSCs in a dose-dependent manner with an apparent Km of 2.3 microM. 3. To examine the presynaptic effect of 5-HT, electrophysiological and optical recordings were made from presynaptic axons. Action potentials evoked Ca(2+) transients in the axons loaded with a Ca(2+)-sensitive dye. 5-HT slightly reduced the Ca(2+) transient. 4. A third-power relationship between Ca(2+) entry and transmitter release was determined. However, presynaptic Ca(2+) currents were unaffected by 5-HT. 5. Further, in the presence of a K(+) channel blocker, 4-aminopyridine (4-AP), 5-HT left unaltered the presynaptic Ca(2+) transient, ruling out the possibility of its direct action on presynaptic Ca(2+) current. 5-HT activated a 4-AP-sensitive current with a reversal potential of -95 mV in these axons. 6. The basal Ca(2+) concentration did not affect 5-HT-mediated inhibition of release. Although 5-HT caused a subtle reduction in resting axonal [Ca(2+)]i, synaptic responses recorded during enhanced resting [Ca(2+)]i, by giving stimulus trains, were equally depressed by 5-HT. 7. 5-HT reduced the frequency of TTX-insensitive spontaneous EPSCs at these synapses, but had no effect on their amplitude. We propose a mechanism of inhibition for transmitter release by 5-HT that is independent of presynaptic Ca(2+) entry.
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