ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Calcium-dependent inhibition of L, N, and P/Q Ca2+ channels in chromaffin cells: role of mitochondria.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Mitochondrial CaBiomolecules · 2026Review
- Mitochondrial calcium cycling in neuronal function and neurodegeneration.Frontiers in cell and developmental biology · 2023Review
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- L-type calcium channels in exocytosis and endocytosis of chromaffin cells.Pflugers Archiv : European journal of physiology · 2018Review
- Regulation by L channels of Ca(2+)-evoked secretory responses in ouabain-treated chromaffin cells.Pflugers Archiv : European journal of physiology · 2016Article
- Tight mitochondrial control of calcium and exocytotic signals in chromaffin cells at embryonic life.Pflugers Archiv : European journal of physiology · 2015Article
- Novel features on the regulation by mitochondria of calcium and secretion transients in chromaffin cells challenged with acetylcholine at 37°C.Physiological reports · 2013Article
- Mitochondria and plasma membrane Ca2+-ATPase control presynaptic Ca2+ clearance in capsaicin-sensitive rat sensory neurons.The Journal of physiology · 2013Article
- Regulation by L-type calcium channels of endocytosis: an overview.Journal of molecular neuroscience : MN · 2012Review
- Multiple Ca2+-dependent mechanisms regulate L-type Ca2+ current in retinal amacrine cells.Journal of neurophysiology · 2010Article
- Calcium balance and mechanotransduction in rat cochlear hair cells.Journal of neurophysiology · 2010Article
- Inhibition of N and PQ calcium channels by calcium entry through L channels in chromaffin cells.Pflugers Archiv : European journal of physiology · 2009Article
- Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?Cell calcium · 2008Article
- Roles of mitochondria and temperature in the control of intracellular calcium in adult rat sensory neurons.Cell calcium · 2008Article
- Mitochondria and Ca(2+) signaling: old guests, new functions.Pflugers Archiv : European journal of physiology · 2007Review
- The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.British journal of pharmacology · 2007Article
- Modulation of mitochondrial Ca(2+) uptake by estrogen receptor agonists and antagonists.British journal of pharmacology · 2005Article
- Presynaptic internal Ca2+ stores contribute to inhibitory neurotransmitter release onto mouse cerebellar Purkinje cells.British journal of pharmacology · 2002Article
- Effect of inositol 1,4,5-trisphosphate receptor stimulation on mitochondrial [Ca2+] and secretion in chromaffin cells.The Biochemical journal · 2002Article
- Mitochondria regulate inactivation of L-type Ca2+ channels in rat heart.The Journal of physiology · 2001Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothesis that the buffering of Ca(2+) by mitochondria could affect the Ca(2+)-dependent inhibition of voltage-activated Ca(2+) channels, (I(Ca)), was tested in voltage-clamped bovine adrenal chromaffin cells. The protonophore carbonyl cyanide m-chlorophenyl-hydrazone (CCCP), the blocker of the Ca(2+) uniporter ruthenium red (RR), and a combination of oligomycin plus rotenone were used to interfere with mitochondrial Ca(2+) buffering. In cells dialyzed with an EGTA-free solution, peak I(Ca) generated by 20 msec pulses to 0 or +10 mV, applied at 15 sec intervals, from a holding potential of -80 mV, decayed rapidly after superfusion of cells with 2 microm CCCP (tau = 16.7 +/- 3 sec; n = 8). In cells dialyzed with 14 mm EGTA, CCCP did not provoke I(Ca) loss. Cell dialysis with 4 microm ruthenium red or cell superfusion with oligomycin (3 microm) plus rotenone (4 microm) also accelerated the decay of I(Ca). After treatment with CCCP, decay of N- and P/Q-type Ca(2+) channel currents occurred faster than that of L-type Ca(2+) channel currents. These data are compatible with the idea that the elevation of the bulk cytosolic Ca(2+) concentration, [Ca(2+)](c), causes the inhibition of L- and N- as well as P/Q-type Ca(2+) channels expressed by bovine chromaffin cells. This [Ca(2+)](c) signal appears to be tightly regulated by rapid Ca(2+) uptake into mitochondria. Thus, it is plausible that mitochondria might efficiently regulate the activity of L, N, and P/Q Ca(2+) channels under physiological stimulation conditions of the cell.
Indexed as
Identifiers
11306608PMC6762545W2143716304What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.