ArticleThe Journal of clinical investigation2001
Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 68 citations in OpenAlex.
- Immunopathological Mechanisms Underlying Cardiac Damage in Chagas Disease.Pathogens (Basel, Switzerland) · 2023Review
- Functional Autoreactive Anti-β2 Adrenergic Antibodies May Contribute to Insulin Resistance Profile in Patients with Chronic Chagas Disease.Pathogens (Basel, Switzerland) · 2021Article
- Chagas disease and systemic autoimmune diseases among Bolivian patients in Switzerland.Memorias do Instituto Oswaldo Cruz · 2018Article
- A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses.Scientific reports · 2017Article
- Inhibition of autoimmune Chagas-like heart disease by bone marrow transplantation.PLoS neglected tropical diseases · 2014Article
- Trypanosoma cruzi Entrance through Systemic or Mucosal Infection Sites Differentially Modulates Regional Immune Response Following Acute Infection in Mice.Frontiers in immunology · 2013Article
- Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs.Journal of tropical medicine · 2012Article
- Pathogenesis of chagas' disease: parasite persistence and autoimmunity.Clinical microbiology reviews · 2011Review
- Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunity.PloS one · 2011Article
- Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.Infection and immunity · 2010Article
- Autoimmune disease triggered by infection with alphaproteobacteria.Expert review of clinical immunology · 2009Article
- The role of infections in autoimmune disease.Clinical and experimental immunology · 2009Review
- Chagas heart disease pathogenesis: one mechanism or many?Current molecular medicine · 2008Review
- A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins.Infection and immunity · 2004Article
- Immunotherapy of Trypanosoma cruzi infection with DNA vaccines in mice.Infection and immunity · 2004Article
- Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties.Infection and immunity · 2001Article
- Antibodies to an epitope from the Cha human autoantigen are markers of Chagas' disease.Clinical and diagnostic laboratory immunology · 2001Article
- Infection, mimics, and autoimmune disease.The Journal of clinical investigation · 2001Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Chagas' disease caused by Trypanosoma cruzi, a paradigm of autoimmune disease, both autoantibodies and autoreactive T cells have been described. We have identified a novel dominant autoantigen, named Cha, recognized by the majority of sera from T. cruzi-infected humans and mice. We noted significant homologies between amino acids 120-129 of Cha, where the B-cell epitope maps, and an expressed sequence tag from T. cruzi, and also between amino acids 254-273 of Cha and a repeated amino acid sequence from the shed acute-phase antigen (SAPA) of T. cruzi. Moreover, T. cruzi-infected mice contain autoreactive T cells that can cross-react with Cha and the SAPA homologous peptides. Transfer of T cells from infected mice triggered anti-Cha (120-129) Ab production in naive recipients. Interestingly, heart tissue sections from those adoptive transferred mice showed cardiac pathology similar to T. cruzi-infected mice. Our results demonstrate the presence of both T- and B-cell cross-reactive epitopes in the Cha antigen. This dual mimicry may lead to T/B cell cooperation and give rise to a pathological immunodominant response against Cha in T. cruzi infected animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.