Trial reportControlled clinical trials2001
The rationale and design of the CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial.
Trial report in Controlled clinical trials, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000922 (A Randomized, Open-Label Study of the Long-Term Effectiveness of Three Initial Highly Active Antiretroviral Therapy), which is not on this map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Open-Label Study of the Long-Term Effectiveness of Three Initial Highly Active Antiretroviral Therapy (HAART) Strategies in HAART-Niave, HIV-Infected Persons
Who cites it
8 citing papers in PubMed.
- Disparities in outcomes for African American and Latino subjects in the Flexible Initial Retrovirus Suppressive Therapies (FIRST) trial.AIDS patient care and STDs · 2010Trial
- Antiretroviral medication adherence and class- specific resistance in a large prospective clinical trial.AIDS (London, England) · 2010Trial
- The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2009Trial
- Differential adherence to combination antiretroviral therapy is associated with virological failure with resistance.AIDS (London, England) · 2008Trial
- Derivation of a Protein Risk Score for Cardiovascular Disease Among a Multiracial and Multiethnic HIV+ Cohort.Journal of the American Heart Association · 2023Article
- Combining Non-randomized and Randomized Data in Clinical Trials Using Commensurate Priors.Health services & outcomes research methodology · 2016Article
- Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases.Journal of acquired immune deficiency syndromes (1999) · 2008Article
- CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection.AIDS (London, England) · 2008Article
Corrections and comments
- Commented on by
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial is a large, long-term, randomized, prospective comparison of three different antiretroviral strategies in highly active antiretroviral therapy-naïve, HIV-1-infected persons. The trial was designed as a flexible framework upon which other studies could be added to answer more limited, but still important, questions. This article presents the study design, discusses the challenges we have faced in implementing the trial, and describes our preliminary experiences. Control Clin Trials 2001;22:176-190
Indexed as
Identifiers
11306155What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.