ArticleBreast cancer research : BCR2001
Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression.
Article in Breast cancer research : BCR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy.Breast cancer research : BCR · 2025Article
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- Aberrant expression of the candidate tumor suppressor gene DAL-1 due to hypermethylation in gastric cancer.Scientific reports · 2016Article
- Tumor suppressor role of protein 4.1B/DAL-1.Cellular and molecular life sciences : CMLS · 2014Review
- The membrane-cytoskeletal protein 4.1N is involved in the process of cell adhesion, migration and invasion of breast cancer cells.Experimental and therapeutic medicine · 2012Article
- Aberrant signaling pathways in meningiomas.Journal of neuro-oncology · 2010Review
- Loss, mutation and deregulation of L3MBTL4 in breast cancers.Molecular cancer · 2010Article
- Identification of 5 novel genes methylated in breast and other epithelial cancers.Molecular cancer · 2010Article
- Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm.Journal of hematopathology · 2009Article
- Protein 4.1B suppresses prostate cancer progression and metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation.Oncogene · 2005Article
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- Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH.Genome research · 2003Article
- The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.The Biochemical journal · 2002Article
- The Potential Effect of Different Doses of Ionizing Radiation on Genes and Disease.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.
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