ArticleGenome biology2001
Conservation of the binding site for the arginine repressor in all bacterial lineages.
Article in Genome biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 93 citations in OpenAlex.
- SEVA: structural and evolutionary feature integration for predicting virulence factors and antibiotic resistance genes.Microbiome · 2026Article
- The ArgR-Regulated ADI Pathway Facilitates the Survival ofInternational journal of molecular sciences · 2024Article
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- Promiscuous plasmid replication in thermophiles: Use of a novel hyperthermophilic replicon for genetic manipulation ofMetabolic engineering communications · 2016Article
- Assessment of transfer methods for comparative genomics of regulatory networks in bacteria.BMC bioinformatics · 2016Article
- Structural Analysis and Insights into the Oligomeric State of an Arginine-Dependent Transcriptional Regulator from Bacillus halodurans.PloS one · 2016Article
- Article
- Article
- Transcription factors and genetic circuits orchestrating the complex, multilayered response of Clostridium acetobutylicum to butanol and butyrate stress.BMC systems biology · 2013Article
- Analysis of the SOS response of Vibrio and other bacteria with multiple chromosomes.BMC genomics · 2012Article
- Inference of self-regulated transcriptional networks by comparative genomics.Evolutionary bioinformatics online · 2012Article
- ArgR of Streptomyces coelicolor is a versatile regulator.PloS one · 2012Article
- Combined effect of improved cell yield and increased specific productivity enhances recombinant enzyme production in genome-reduced Bacillus subtilis strain MGB874.Applied and environmental microbiology · 2011Article
- Deciphering the transcriptional regulatory logic of amino acid metabolism.Nature chemical biology · 2011Article
- Comparative genomic reconstruction of transcriptional networks controlling central metabolism in the Shewanella genus.BMC genomics · 2011Article
- Interaction of transcriptional repressor ArgR with transcriptional regulator FarR at the argB promoter region in Corynebacterium glutamicum.Applied and environmental microbiology · 2011Article
- Exploiting antigenic diversity for vaccine design: the chlamydia ArtJ paradigm.The Journal of biological chemistry · 2010Article
- ArgR-regulated genes are derepressed in the Legionella-containing vacuole.Journal of bacteriology · 2010Article
- fpr, a deficient Xer recombination site from a Salmonella plasmid, fails to confer stability by dimer resolution: comparative studies with the pJHCMW1 mwr site.Journal of bacteriology · 2010Article
- RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes.Nucleic acids research · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe arginine repressor ArgR/AhrC is a transcription factor universally conserved in bacterial genomes. Its recognition signal (the ARG box), a weak palindrome, is also conserved between genomes, despite a very low degree of similarity between individual sites within a genome. Thus, the arginine repressor is different from two other universal transcription factors - HrcA, whose recognition signal is very strongly conserved both within and between genomes, and LexA/DinR, whose signal is strongly conserved within, but not between, genomes. The arginine regulon is well studied in Escherichia coli and to some extent in Bacillus subtilis and some other genomes. Here, we apply the comparative genomic approach to the prediction of the ArgR-binding sites in all completely sequenced bacterial genomes.
resultsOrthologs of ArgR/AhrC were identified in the complete genomes of E. coli, Haemophilus influenzae, Vibrio choleras, B. subtilis, Mycobacterium tuberculosis, Thermotoga maritima, Chlamydia pneumoniae and Deinococcus radiodurans. Candidate arginine repressor binding sites were identified upstream of arginine transport and metabolism genes.
conclusionsWe found that the ArgR/AhrC recognition signal is conserved in all genomes that contain genes encoding orthologous transcription factors of this family. All genomes studied except M. tuberculosis contain ABC transport cassettes (related to the Art system of E. coli) belonging to the candidate arginine regulons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.