ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2001
Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration.
Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 241 citations in OpenAlex.
- Methadone for neuropathic pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Methadone for cancer pain.The Cochrane database of systematic reviews · 2017Pooled it
- Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.Pediatric blood & cancer · 2016Trial
- Pharmacokinetics of a new immediate-release methadone tablet formulation with decreased in vitro solubility.Clinical drug investigation · 2012Trial
- The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study.Journal of palliative medicine · 2010Trial
- The role of methadone in opioid rotation-a Polish experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2009Trial
- Article
- Efficacy and safety of combining low-dose methadone with ongoing opioid treatment for uncontrolled cancer pain: an open-label single-arm study.The oncologist · 2025Observational
- Predicting the Risk of Opioid-induced Respiratory Depression Using ChatGPT-4o and Machine Learning Techniques.Archives of academic emergency medicine · 2025Article
- Low-dose methadone added to another opioid for cancer pain: a multicentre prospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- The Use of Low-Dose Methadone as Add-On to Ongoing Opioid Treatment in Palliative Cancer Care-An Underrated Treatment?Life (Basel, Switzerland) · 2022Review
- The role of methadone in cancer-induced bone pain: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- The American Society of Pain and Neuroscience (ASPN) Best Practices and Guidelines for the Interventional Management of Cancer-Associated Pain.Journal of pain research · 2021Review
- Methadone for Pain Management: A Pharmacotherapeutic Review.CNS drugs · 2020Review
- Pharmacogenomics of methadone: a narrative review of the literature.Pharmacogenomics · 2020Review
- Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study.Cardiology and therapy · 2020Article
- Methadone in Swedish specialized palliative care-Is it the magic bullet in complex cancer-related pain?PloS one · 2020Article
- Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic Mice.Frontiers in pharmacology · 2020Article
- Comprehensive Perioperative Management Considerations in Patients Taking Methadone.Current pain and headache reports · 2019Review
- Preoperative oral methadone for postoperative pain in patients undergoing cardiac surgery: A randomized double-blind placebo-controlled pilot.Canadian journal of pain = Revue canadienne de la douleur · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions. Several guidelines of administration have been established. Physicians who are involved in pain management should have a fundamental understanding of methadone's unique properties.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.