ArticleBrain pathology (Zurich, Switzerland)2001
Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy.
Article in Brain pathology (Zurich, Switzerland), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 37 citations in OpenAlex.
- Expression of synaptic proteins and development of dendritic spines in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa.Brain structure & function · 2025Article
- Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors.The Journal of clinical investigation · 2023Article
- High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus.Scientific reports · 2021Article
- Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus.Neural plasticity · 2017Article
- Reelin Exerts Structural, Biochemical and Transcriptional Regulation Over Presynaptic and Postsynaptic Elements in the Adult Hippocampus.Frontiers in cellular neuroscience · 2016Article
- Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice.Frontiers in synaptic neuroscience · 2015Article
- Potential role of drebrin a, an f-actin binding protein, in reactive synaptic plasticity after pilocarpine-induced seizures: functional implications in epilepsy.International journal of cell biology · 2012Article
- Gelsolin in cerebrospinal fluid as a potential biomarker of epilepsy.Neurochemical research · 2011Article
- Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats.BMC neuroscience · 2010Article
- Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Stabilizing dendritic structure as a novel therapeutic approach for epilepsy.Expert review of neurotherapeutics · 2008Review
- Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes.Brain research · 2007Article
- Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptopodin, a 100 kD protein, associated with the actin cytoskeleton of the postsynaptic density and dendritic spines, is thought to play a role in modulating actin-based shape and motility of dendritic spines during formation or elimination of synaptic contacts. Temporal lobe epilepsy in humans and in rats shows neuronal damage, aberrant sprouting of hippocampal mossy fibers and subsequent synaptic remodeling processes. Using kainic acid (KA) induced epilepsy in rats, the postictal hippocampal expression of synaptopodin was analyzed by in situ hybridization (ISH) and immunohistochemistry. Sprouting of mossy fibers was visualized by a modified Timm's staining. ISH showed elevated levels of Synaptopodin mRNA in perikarya of CA3 principal neurons, dentate granule cells and in surviving hilar neurons these levels persisted up to 8 weeks after seizure induction. Synaptopodin immunoreactivity in the dendritic layers of CA3, in the hilus and in the inner molecular layer of the dentate gyrus (DG) was initially reduced. Eight weeks after KA treatment Synaptopodin protein expression returned to control levels in dendritic layers of CA3 and in the entire molecular layer of the DG. The recovery of protein expression was accompanied by simultaneous supra- and infragranular mossy fiber sprouting. Postictal upregulation of Synaptopodin mRNA levels in target cell populations of limbic epilepsy-elicited damage and subsequent Synaptopodin protein expression largely co-localized with remodeling processes as demonstrated by mossy fiber sprouting. It may thus represent a novel postsynaptic molecular correlate of hippocampal neuroplasticity.
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