ArticleGut2001
Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice.
Article in Gut, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Sleep Disturbances Associated with Different Systems of the Body: Underlying Mechanisms Involved and Consequences.Current medicinal chemistry · 2025Review
- Long sleep duration and good sleep quality reduced incident peptic ulcer disease in a large Taiwanese population follow-up study.International journal of medical sciences · 2025Article
- The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer.Cell death discovery · 2024Review
- The Forms of the Lectin Tff2 Differ in the Murine Stomach and Pancreas: Indications for Different Molecular Functions.International journal of molecular sciences · 2023Article
- Circadian clocks in the digestive system.Nature reviews. Gastroenterology & hepatology · 2021Review
- Effects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization.Oxidative medicine and cellular longevity · 2021Article
- Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm.International journal of molecular sciences · 2020Review
- The TFF Peptides xP1 and xP4 Appear in Distinctive Forms in theInternational journal of molecular sciences · 2019Article
- Different Forms of TFF2, A Lectin of the Human Gastric Mucus Barrier:International journal of molecular sciences · 2019Article
- Circadian rhythms: a regulator of gastrointestinal health and dysfunction.Expert review of gastroenterology & hepatology · 2019Review
- Aspirin for the older person: report of a meeting at the Royal Society of Medicine, London, 3rd November 2011.Ecancermedicalscience · 2012Article
- Pathophysiological investigation of the gastric surface mucous gel layer of patients with Helicobacter pylori infection by using immunoassays for trefoil factor family 2 and gastric gland mucous cell-type mucin in gastric juice.Digestive diseases and sciences · 2011Article
- Correlates shift work with increased risk of gastrointestinal complaints or frequency of gastritis or peptic ulcer in H. pylori-infected shift workers?International archives of occupational and environmental health · 2010Article
- Improving the gastrointestinal tolerability of aspirin in older people.Clinical interventions in aging · 2006Review
- Effect of age-related changes in gastric physiology on tolerability of medications for older people.Drugs & aging · 2005Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTFF2, a member of the trefoil factor family of proteins, is a glycosylated protein of 106 amino acids. It is secreted by gastric antral and pyloric glands and by Brunner's glands of the duodenum. TFF2 is found in high concentrations around sites of ulceration. It stimulates cell motility and is probably the principal cytoprotective trefoil peptide in the stomach.
aimsTo determine if production of TFF2 follows a circadian rhythm and to measure changes in secretion of TFF2 in response to food intake and during sleep. SUBJECTS: Young healthy adults were recruited. They were asymptomatic and were not receiving medication. The 24 hour regimen was designed to allow normal stimulation of gastric secretion in response to food intake and sleep. Gastric juice was collected two hourly via a nasogastric tube.
methodsGlycosylated and non-glycosylated TFF2 proteins were measured by quantitative western transfer analysis. The results were analysed statistically using SPSS software.
resultsThere was a dramatic diurnal variation in the concentration of TFF2. The mean concentration was lowest in the early evening (0.29 microg/ml), increased gradually during the evening, and then sharply during the night to reach 7.9 microg/ml. The ratio of glycosylated to non-glycosylated TFF2 varied and was higher during the night than in the afternoon. pH, total protein, and pepsin concentrations in gastric juice did not vary significantly over 24 hours.
conclusionThe data suggest that diurnal variations in TFF2 secretion occur independently of pepsin and gastric acid secretion. The concentration of glycosylated TFF2 in the gastric lumen falls in response to food intake. TFF2 secretion increases during inactivity and sleep. These results suggest that secretion of TFF2 in the stomach is highest during the night and that the cytoprotective effects of TFF2 on the gastric mucosa occur mainly during sleep.
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