Evidence map›Paper›PMID 11302837›Full record

ArticleAntimicrobial agents and chemotherapy2001

Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14.

F Nicoletti, R Di Marco, P Sacerdote, P Meroni, K Mangano, C Edwards, A Bartorelli, K Bendtzen, A Panerai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

F NicolettiDepartment of Clinical Medicine, Prevention and Biotechnological Health, University of Milan Bicocca, Italy. ferdinic@ctonline.it
R Di Marco
P Sacerdote
P Meroni
K Mangano
C Edwards
A Bartorelli
K Bendtzen
A Panerai
University of Catania · ITAmgen (United States) · USGiorgio Cini Foundation · ITNational University Hospital · SGUniversity of Milan · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.

Indexed as

ProteinsRibonucleasesAdjuvants, ImmunologicAnimalsDisease Models, AnimalEndotoxemiaFemaleHeat-Shock ProteinsInterferon-gammaLipopolysaccharidesMiceMice, Inbred BALB CTreatment OutcomeTumor Necrosis Factor-alphaAdjuvants, ImmunologicHeat-Shock ProteinsInterferon-gammaLipopolysaccharidesMFP14 protein, mouseProteinsRibonucleasesTumor Necrosis Factor-alpha

Identifiers

PMID11302837
PMCPMC90515
OpenAlexW2115298441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.