ArticleAntimicrobial agents and chemotherapy2001
Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice.
Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- The inflammatory spectrum of cardiomyopathies.Frontiers in cardiovascular medicine · 2024Review
- Myocardial Function in Fetuses with Congenital Cytomegalovirus Infection.Fetal diagnosis and therapy · 2023Article
- Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis.The Journal of experimental medicine · 2022Article
- Don't Go Breaking My Heart: MCMV as a Model for HCMV-Associated Cardiovascular Diseases.Pathogens (Basel, Switzerland) · 2021Review
- Heart Dysfunction Following Long-Term Murine Cytomegalovirus Infection: Fibrosis, Hypertrophy, and Tachycardia.Viral immunology · 2020Article
- Caspase-8 restricts antiviral CD8 T cell hyperaccumulation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularization.PLoS pathogens · 2012Article
- Ganciclovir transiently attenuates murine cytomegalovirus-associated renal allograft inflammation.Transplantation · 2011Article
- Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir.Wiener klinische Wochenschrift · 2010Article
- Antiviral prevention of sepsis induced cytomegalovirus reactivation in immunocompetent mice.Antiviral research · 2010Article
- Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo.Archives of virology · 2009Article
- Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections.Clinical microbiology reviews · 2003Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cardiovascular disease myocarditis is characterized by inflammation and necrosis of cardiac muscle. This disease has been associated with various viral etiologies, including cytomegalovirus (CMV). Murine CMV (MCMV) infection of adult BALB/c mice produces a disease with acute and chronic phases similar to that found in humans. In our murine model, we have investigated the therapeutic efficacy of antiviral drug administration on myocarditis. Two drugs commonly used for CMV treatment, ganciclovir and cidofovir, were subjected to trials, with both drugs showing potent antiviral activity against MCMV both in vitro and in vivo. The acute phase of myocarditis was significantly reduced when antiviral therapy commenced 24 h postinfection. Such treatment also reduced the severity of the chronic phase of myocarditis. In contrast, antiviral treatment commencing after the acute phase had no effect on chronic myocarditis. Reinfection of mice with MCMV caused exacerbation of myocardial inflammation. Such an increase in severity of myocarditis could be prevented with either ganciclovir or cidofovir treatment, but the preexisting inflammation and necrosis of the myocardium persisted. These data highlight possible therapeutic uses of antiviral drugs in viral myocarditis as well as further elucidating the pathogenic nature of the disease.
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