ArticlePlant physiology2001
Carrier-mediated uptake and phloem systemy of a 350-Dalton chlorinated xenobiotic with an alpha-amino acid function.
Article in Plant physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Salicylic acid: a key natural foundation for next-generation plant defense stimulators.Pest management science · 2026Review
- AgroDrug Conjugates for Sustainable Crop Protection: Molecular Architectures, Mechanisms, and Critical Perspectives.Topics in current chemistry (Cham) · 2025Review
- Synthesis, phloem mobility and induced plant resistance of synthetic salicylic acid amino acid or glucose conjugates.Pest management science · 2022Article
- An Exploration of the Effect of the Kleier Model and Carrier-Mediated Theory to Design Phloem-Mobile Pesticides Based on Researching the N-Alkylated Derivatives of Phenazine-1-Carboxylic Acid-Glycine.Molecules (Basel, Switzerland) · 2022Article
- Uptake and transport of antibiotic kasugamycin in castor bean (Frontiers in microbiology · 2022Article
- Synthesis, bioactivities and phloem uptake of dipeptide-chlorantraniliprole derivatives.BMC chemistry · 2020Article
- Overexpression of AtAAP1 increased the uptake of an alanine-chlorantraniliprole conjugate in Arabidopsis thaliana.Environmental science and pollution research international · 2019Article
- Vectorization of agrochemicals: amino acid carriers are more efficient than sugar carriers to translocate phenylpyrrole conjugates in the Ricinus system.Environmental science and pollution research international · 2018Article
- Synthesis of Novel Amino Acid-Fipronil Conjugates and Study on Their Phloem Loading Mechanism.Molecules (Basel, Switzerland) · 2018Article
- Use of D-glucose-fenpiclonil conjugate as a potent and specific inhibitor of sucrose carriers.Journal of experimental botany · 2017Article
- Influence of Pyranose and Spacer Arm Structures on Phloem Mobility and Insecticidal Activity of New Tralopyril Derivatives.Molecules (Basel, Switzerland) · 2017Article
- 2,4-D resistance in wild radish: reduced herbicide translocation via inhibition of cellular transport.Journal of experimental botany · 2016Article
- Synthesis and evaluation as biodegradable herbicides of halogenated analogs of L-meta-tyrosine.Environmental science and pollution research international · 2014Article
- Salicylic acid, an ambimobile molecule exhibiting a high ability to accumulate in the phloem.Plant physiology · 2006Article
- Genes and proteins for solute transport and sensing.The arabidopsis book · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous paper we have shown that epsilon-(phenoxyalkanecarboxylyl)-L-Lys conjugates are potent inhibitors of amino acid transport systems and that it is possible to modulate the uptake inhibition by hydrophobic or hydrophilic additions in the 4-position of the aromatic ring (J.F. Chollet, C. Delétage, M. Faucher, L. Miginiac, J.L. Bonnemain [1997] Biochem Biophys Acta 1336: 331-341). In this report we demonstrate that epsilon-(2,4-dichlorophenoxyacetyl)-L-Lys (2,4D-Lys), one of the largest molecules of the series and one of the most potent inhibitors, is a highly permeant conjugate. Uptake of 2,4D-Lys by broad bean (Vicia faba) leaf discs is mediated by an active carrier system (Km1 = 0.2 mM; Vmax1 = 2.4 nmol x cm(-2) x h(-1) at pH 5.0) complemented by an important diffusive component. Among the compounds tested (neutral, basic, and acidic amino acids, auxin, glutathione, and sugars), only the aromatic amino acids clearly compete with 2,4D-Lys. The conjugate accumulates in the vein network, is exported toward the growing organs, and exhibits a distribution pattern different from that of the herbicide moiety. However, over time 2,4D-Lys progressively splits into 2,4D and lysine. Analyses by high-performance liquid chromatography and liquid scintillation spectrometry of the phloem sap collected from the castor bean system, used as a systemy test, indicate decreasing capacities of 2,4D, 2,4D-Lys, and glyphosate, respectively, to move from the epidermis cell wall to the sieve element. Our results show that it is possible to design synthesis of large-size xenobiotics (approximately 350 D) with a lipophilic pole, exhibiting high mobility within the vascular system.
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