ArticleThe European journal of neuroscience2001
NMDA-evoked calcium transients and currents in the suprachiasmatic nucleus: gating by the circadian system.
Article in The European journal of neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Article
- Single cell model for re-entrainment to a shifted light cycle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling.Ageing research reviews · 2022Review
- AMPA Receptor Function in Hypothalamic Synapses.Frontiers in synaptic neuroscience · 2022Review
- SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity.The European journal of neuroscience · 2021Article
- Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability.Physiological reviews · 2020Review
- TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses.Nature communications · 2020Article
- Molecular Mechanisms Underlying the Circadian Rhythm of Blood Pressure in Normotensive Subjects.Current hypertension reports · 2020Review
- A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.International journal of molecular sciences · 2019Review
- SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of the Circadian System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus.The European journal of neuroscience · 2017Article
- Role of vasoactive intestinal peptide in the light input to the circadian system.The European journal of neuroscience · 2015Article
- The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Circadian gating of neuronal functionality: a basis for iterative metaplasticity.Frontiers in systems neuroscience · 2014Review
- The role of PPARβ/δ in the regulation of glutamatergic signaling in the hamster suprachiasmatic nucleus.Cellular and molecular life sciences : CMLS · 2013Article
- cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.PloS one · 2012Article
- A multicellular model for differential regulation of circadian signals in the core and shell regions of the suprachiasmatic nucleus.Journal of theoretical biology · 2011Article
- Linking neural activity and molecular oscillations in the SCN.Nature reviews. Neuroscience · 2011Review
- Fast delayed rectifier potassium current: critical for input and output of the circadian system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A variety of evidence suggests that the effects of light on the mammalian circadian system are mediated by glutamatergic mechanisms and that the N-methyl- D-aspartate (NMDA) receptor plays an important role in this regulation. One of the fundamental features of circadian oscillators is that their response to environmental stimulation varies depending on the phase of the daily cycle when the stimuli are applied. For example, the same light treatment, which can produce phase shifts of the oscillator when applied during subjective night, has no effect when applied during the subjective day in animals held in constant darkness (DD). We examined the hypothesis that the effects of NMDA on neurons in the suprachiasmatic nucleus (SCN) also vary from day to night. Optical techniques were utilized to estimate NMDA-induced calcium (Ca2+) changes in SCN cells. The resulting data indicate that there was a daily rhythm in the magnitude and duration of NMDA-induced Ca2+ transients. The phase of this rhythm was determined by the light-dark cycle to which the rats were exposed with the Ca2+ transients peaking during the night. This rhythm continued when animals were held in DD. gamma-Aminobutyric acid (GABA)ergic mechanisms modulated the NMDA response but were not responsible for the rhythm. Finally, there was a rhythm in NMDA-evoked currents in SCN neurons that also peaked during the night. This study provides the first evidence for a circadian oscillation in NMDA-evoked Ca2+ transients in SCN cells. This rhythm may play an important role in determining the periodic sensitivity of the circadian systems response to light.
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Registered trials
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