ArticleProceedings of the National Academy of Sciences of the United States of America2001
Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- The radiophiles of Deinococcaceae family: Resourceful microbes for innovative biotechnological applications.Current research in microbial sciences · 2022Review
- Response ofPeerJ · 2021Article
- Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning.F1000Research · 2018Article
- The S-layer Protein DR_2577 Binds Deinoxanthin and under Desiccation Conditions Protects against UV-Radiation in Deinococcus radiodurans.Frontiers in microbiology · 2016Article
- Molecular investigation of the radiation resistance of edible cyanobacterium Arthrospira sp. PCC 8005.MicrobiologyOpen · 2015Article
- Sequence of the hyperplastic genome of the naturally competent Thermus scotoductus SA-01.BMC genomics · 2011Article
- Oxidative stress resistance in Deinococcus radiodurans.Microbiology and molecular biology reviews : MMBR · 2011Review
- Comparative analysis of sequence periodicity among prokaryotic genomes points to differences in nucleoid structure and a relationship to gene expression.Journal of bacteriology · 2010Article
- Article
- Deinococcus radiodurans PprI switches on DNA damage response and cellular survival networks after radiation damage.Molecular & cellular proteomics : MCP · 2009Article
- Gene Expression Analysis of Four Radiation-resistant Bacteria.Genomics insights · 2009Article
- Unusual codon usage bias in low expression genes of Vibrio cholerae.Bioinformation · 2008Article
- Protein oxidation implicated as the primary determinant of bacterial radioresistance.PLoS biology · 2007Article
- Distinguishing features of delta-proteobacterial genomes.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- A comparative categorization of protein function encoded in bacterial or archeal genomic islands.Journal of molecular evolution · 2006Article
- Distinctive protein signatures provide molecular markers and evidence for the monophyletic nature of the deinococcus-thermus phylum.Journal of bacteriology · 2004Article
- Comparative analysis of gene expression among low G+C gram-positive genomes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Predicting gene expression levels from codon biases in alpha-proteobacterial genomes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- New technology may reveal mechanisms of radiation resistance in Deinococcus radiodurans.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- RecA Protein from the extremely radioresistant bacterium Deinococcus radiodurans: expression, purification, and characterization.Journal of bacteriology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Predicted highly expressed (PHX) and putative alien genes determined by codon usages are characterized in the genome of Deinococcus radiodurans (strain R1). Deinococcus radiodurans (DEIRA) can survive very high doses of ionizing radiation that are lethal to virtually all other organisms. It has been argued that DEIRA is endowed with enhanced repair systems that provide protection and stability. However, predicted expression levels of DNA repair proteins with the exception of RecA tend to be low and do not distinguish DEIRA from other prokaryotes. In this paper, the capability of DEIRA to resist extreme doses of ionizing and UV radiation is attributed to an unusually high number of PHX chaperone/degradation, protease, and detoxification genes. Explicitly, compared with all current complete prokaryotic genomes, DEIRA contains the greatest number of PHX detoxification and protease proteins. Other sources of environmental protection against severe conditions of UV radiation, desiccation, and thermal effects for DEIRA are the several S-layer (surface structure) PHX proteins. The top PHX gene of DEIRA is the multifunctional tricarboxylic acid (TCA) gene aconitase, which, apart from its role in respiration, also alerts the cell to oxidative damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.