ArticleProceedings of the National Academy of Sciences of the United States of America2001
Vitamin B12 and hepatitis C: molecular biology and human pathology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-naïve patients.World journal of gastroenterology · 2011Trial
- Evaluation of Cardiovascular Risk Factors after Hepatitis C Virus Eradication with Direct-Acting Antivirals in a Cohort of Treatment-Naïve Patients without History of Cardiovascular Disease.Journal of clinical medicine · 2022Article
- Medicinal Animals and Plants as Alternative and Complementary Medicine in Southern Regions of Khyber Pakhtunkhwa, Pakistan.Frontiers in pharmacology · 2021Article
- The Presence of Circulating Nucleated Red Blood Cells Is Associated With Disease Severity in Patients of Hemorrhagic Fever With Renal Syndrome.Frontiers in medicine · 2021Article
- COVID-19's toll on the elderly and those with diabetes mellitus - Is vitamin B12 deficiency an accomplice?Medical hypotheses · 2021Review
- New opportunities for designing effective small interfering RNAs.Scientific reports · 2019Article
- The Role of Micronutrients in the Infection and Subsequent Response to Hepatitis C Virus.Cells · 2019Review
- Association of serum vitamin B12 levels with stage of liver fibrosis and treatment outcome in patients with chronic hepatitis C virus genotype 1 infection: a retrospective study.BMC research notes · 2015Article
- Individualized therapy for hepatitis C infection: focus on the interleukin-28B polymorphism in directing therapy.Molecular diagnosis & therapy · 2014Review
- HCV IRES-mediated core expression in zebrafish.PloS one · 2013Article
- Novel function of CD81 in controlling hepatitis C virus replication.Journal of virology · 2010Article
- Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.Antimicrobial agents and chemotherapy · 2007Article
- Differential effects on the hepatitis C virus (HCV) internal ribosome entry site by vitamin B12 and the HCV core protein.Journal of virology · 2004Article
- Inhibition of hepatitis C virus IRES-mediated translation by small RNAs analogous to stem-loop structures of the 5'-untranslated region.Nucleic acids research · 2004Article
- Inhibition of translation by RNA-small molecule interactions.RNA (New York, N.Y.) · 2002Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cobalamins are stored in high concentrations in the human liver and thus are available to participate in the regulation of hepatotropic virus functions. We show that cyanocobalamin (vitamin B12) inhibited the HCV internal ribosome entry site (IRES)-dependent translation of a reporter gene in vitro in a dose-dependent manner without significantly affecting the cap-dependent mechanism. Vitamin B12 failed to inhibit translation by IRES elements from encephalomyocarditis virus (EMCV) or classical swine fever virus (CSFV). We also demonstrate a relationship between the total cobalamin concentration in human sera and HCV viral load (a measure of viral replication in the host). The mean viral load was two orders of magnitude greater when the serum cobalamin concentration was above 200 pM (P < 0.003), suggesting that the total cobalamin concentration in an HCV-infected liver is biologically significant in HCV replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.