ArticleProceedings of the National Academy of Sciences of the United States of America2001
Activation of a protease cascade involved in patterning the Drosophila embryo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Cephalic ganglia transcriptomics of the American cockroach Periplaneta americana (Blattodea: Blattidae).Journal of insect science (Online) · 2024Article
- Article
- The Set of Serine Peptidases of theInternational journal of molecular sciences · 2024Article
- Identification and gene expression analysis of serine proteases and their homologs in the Asian corn borer Ostrinia furnacalis.Scientific reports · 2023Article
- Isolation of secreted proteins from Drosophila ovaries and embryos through in vivo BirA-mediated biotinylation.PloS one · 2019Article
- Genome-Wide Host-Pathogen Interaction Unveiled by Transcriptomic Response of Diamondback Moth to Fungal Infection.PloS one · 2016Article
- Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor.Structure (London, England : 1993) · 2013Article
- A ventrally localized protease in the Drosophila egg controls embryo dorsoventral polarity.Current biology : CB · 2012Article
- Cloning and the expression pattern of Spätzle gene during embryonic development and bacterial challenge in Artemia sinica.Molecular biology reports · 2012Article
- Proteomic analysis of ripening tomato fruit infected by Botrytis cinerea.Journal of proteome research · 2012Article
- Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation.PloS one · 2012Article
- Emerging principles in protease-based drug discovery.Nature reviews. Drug discovery · 2010Review
- Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.FEBS letters · 2010Article
- Pipe-dependent ventral processing of Easter by Snake is the defining step in Drosophila embryo DV axis formation.Current biology : CB · 2010Article
- Molecular mechanism that induces activation of Spätzle, the ligand for the Drosophila Toll receptor.The Journal of biological chemistry · 2010Article
- Proteolytic activation and function of the cytokine Spätzle in the innate immune response of a lepidopteran insect, Manduca sexta.The FEBS journal · 2010Article
- Graded dorsal and differential gene regulation in the Drosophila embryo.Cold Spring Harbor perspectives in biology · 2009Review
- Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe.Development (Cambridge, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dorsoventral patterning of the Drosophila embryo is initiated by a ventralizing signal. Production of this signal requires the serine proteases Gastrulation Defective (GD), Snake, and Easter, which genetic studies suggest act sequentially in a cascade that is activated locally in response to a ventral cue provided by the pipe gene. Here, we demonstrate biochemically that GD activates Snake, which in turn activates Easter. We also provide evidence that GD zymogen cleavage is important for triggering this cascade but is not spatially localized by pipe. Our results suggest that a broadly, rather than locally, activated protease cascade produces the ventralizing signal, so a distinct downstream step in this cascade must be spatially regulated to restrict signaling to the ventral side of the embryo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.