ArticleProceedings of the National Academy of Sciences of the United States of America2001
The ricinosomes of senescing plant tissue bud from the endoplasmic reticulum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 122 citations in OpenAlex.
- Specialized endoplasmic reticulum-derived vesicles in plants: Functional diversity, evolution, and biotechnological exploitation.Journal of integrative plant biology · 2022Review
- Coping with Abiotic Stress in Plants-An Endomembrane Trafficking Perspective.Plants (Basel, Switzerland) · 2022Review
- Genomic Characterization and Expressional Profiles of Autophagy-Related Genes (International journal of molecular sciences · 2020Article
- Endoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants.Communications biology · 2020Article
- Barley cysteine protease PAP14 plays a role in degradation of chloroplast proteins.Journal of experimental botany · 2019Article
- Plant proteases during developmental programmed cell death.Journal of experimental botany · 2019Review
- The role of KDEL-tailed cysteine endopeptidases of Arabidopsis (AtCEP2 and AtCEP1) in root development.PloS one · 2018Article
- Activation of Nucleases, PCD, and Mobilization of Reserves in theFrontiers in plant science · 2018Article
- Article
- Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.The Journal of biological chemistry · 2016Article
- Inhibitory properties of cysteine protease pro-peptides from barley confer resistance to spider mite feeding.PloS one · 2015Article
- Ex vivo processing for maturation of Arabidopsis KDEL-tailed cysteine endopeptidase 2 (AtCEP2) pro-enzyme and its storage in endoplasmic reticulum derived organelles.Plant molecular biology · 2014Article
- Flower senescence: some molecular aspects.Planta · 2014Review
- ER bodies in plants of the Brassicales order: biogenesis and association with innate immunity.Frontiers in plant science · 2014Review
- Endoplasmic reticulum KDEL-tailed cysteine endopeptidase 1 of Arabidopsis (AtCEP1) is involved in pathogen defense.Frontiers in plant science · 2014Article
- Ricinosomes provide an early indicator of suspensor and endosperm cells destined to die during late seed development in quinoa (Chenopodium quinoa).Annals of botany · 2013Article
- Unconventional pathways of secretory plant proteins from the endoplasmic reticulum to the vacuole bypassing the Golgi complex.Plant signaling & behavior · 2013Review
- Induction of a ricinosomal-protease and programmed cell death in tomato endosperm by gibberellic acid.Planta · 2013Article
- Identification of two novel endoplasmic reticulum body-specific integral membrane proteins.Plant physiology · 2013Article
- Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ricinosome (synonym, precursor protease vesicle) is a novel organelle, found so far exclusively in plant cells. Electron microscopic studies suggest that it buds off from the endoplasmic reticulum in senescing tissues. Biochemical support for this unusual origin now comes from the composition of the purified organelle, which contains large amounts of a 45-kDa cysteine endoprotease precursor with a C-terminal KDEL motif and the endoplasmic reticulum lumen residents BiP (binding protein) and protein disulfide isomerase. Western blot analysis, peptide sequencing, and mass spectrometry demonstrate retention of KDEL in the protease proform. Acidification of isolated ricinosomes causes castor bean cysteine endopeptidase activation, with cleavage of the N-terminal propeptide and the C-terminal KDEL motif. We propose that ricinosomes accumulate during senescence by programmed cell death and are activated by release of protons from acidic vacuoles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.