ArticleMolecular biology of the cell2001
A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 125 citations in OpenAlex.
- Designed Cell-Penetrating Peptide Constructs for Inhibition of Pathogenic Protein Self-Assembly.Pharmaceutics · 2024Review
- Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Bombyx mori Nucleopolyhedrovirus GP64 Retains the Transmembrane Helix of Signal Peptide to Contribute to Secretion across the Cytomembrane.Microbiology spectrum · 2022Article
- Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets.Frontiers in neuroscience · 2022Review
- Activation of the PDGF β Receptor by a Persistent Artificial Signal Peptide.Journal of molecular biology · 2021Article
- Prions, prionoids and protein misfolding disorders.Nature reviews. Genetics · 2018Review
- Dimerization of the cellular prion protein inhibits propagation of scrapie prions.The Journal of biological chemistry · 2018Article
- JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain.Scientific reports · 2017Article
- Physiological Functions of the Cellular Prion Protein.Frontiers in molecular biosciences · 2017Review
- Early Vertebrate Evolution of the Host Restriction Factor Tetherin.Journal of virology · 2015Article
- The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.The Journal of biological chemistry · 2015Article
- An uncleaved signal peptide directs the Malus xiaojinensis iron transporter protein Mx IRT1 into the ER for the PM secretory pathway.International journal of molecular sciences · 2014Article
- Counteraction of the multifunctional restriction factor tetherin.Frontiers in microbiology · 2014Review
- Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.Human molecular genetics · 2013Article
- Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.The Journal of biological chemistry · 2012Article
- Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein.The Journal of biological chemistry · 2011Article
- Tetherin and its viral antagonists.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Review
- Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.PloS one · 2010Article
- Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.Molecular biology of the cell · 2010Article
- Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although there is considerable evidence that PrP(Sc) is the infectious form of the prion protein, it has recently been proposed that a transmembrane variant called (Ctm)PrP is the direct cause of prion-associated neurodegeneration. We report here, using a mutant form of PrP that is synthesized exclusively with the (Ctm)PrP topology, that (Ctm)PrP is retained in the endoplasmic reticulum and is degraded by the proteasome. We also demonstrate that (Ctm)PrP contains an uncleaved, N-terminal signal peptide as well as a C-terminal glycolipid anchor. These results provide insight into general mechanisms that control the topology of membrane proteins during their synthesis in the endoplasmic reticulum, and they also suggest possible cellular pathways by which (Ctm)PrP may cause disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.