ArticleGenetica2000
A trans-activator on the Drosophila Y chromosome regulates gene expression in the male germ line.
Article in Genetica, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Dissecting Fertility Functions ofGenetics · 2020Article
- The organization and evolution of the Responder satellite in species of the Drosophila melanogaster group: dynamic evolution of a target of meiotic drive.BMC evolutionary biology · 2014Article
- Endogenously imprinted genes in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2014Article
- Genome-wide gene expression effects of sex chromosome imprinting in Drosophila.G3 (Bethesda, Md.) · 2014Article
- How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression.Journal of genomics · 2014Review
- Male-specific Y-linked transgene markers to enhance biologically-based control of the Mexican fruit fly, Anastrepha ludens (Diptera: Tephritidae).BMC genetics · 2014Article
- Surprising differences in the variability of Y chromosomes in African and cosmopolitan populations of Drosophila melanogaster.Genetics · 2013Article
- Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Y chromosome of Drosophila melanogaster accounts for approximately 13% of a normal male genome and is entirely heterochromatic. It carries six genes required exclusively for spermatogenesis. Here we report a novel activity of the Y chromosome that regulates gene expression in primary spermatocytes. By examining the expression of a reporter gene in X/Y and X/O males, we show that a specific region of the Y long arm carries a trans-activator that regulates transcription in spermatogenesis. In the absence of the Y trans-activator, the level of the reporter expression is greatly reduced in primary spermatocytes and the expression pattern is restricted to young primary spermatocytes. Further analysis shows that the Y trans-activator is dispersed in the h1-h10 region on the Y long arm and is functionally redundant, indicating involvement of the repetitive sequences on the Y chromosome. In addition, the Y trans-activator appears to act in a tissue-specific manner, functioning only in the male germ line. We propose that the Y trans-activator plays an important role in regulating gene expression during spermatogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.