ArticleNucleic acids research2001
Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Meta-analysis of small RNA-sequencing errors reveals ubiquitous post-transcriptional RNA modifications.Nucleic acids research · 2009Pooled it
- Genomic factors shaping codon usage across the Saccharomycotina subphylum.G3 (Bethesda, Md.) · 2024Article
- Review
- Functions and regulation of the APOBEC family of proteins.Seminars in cell & developmental biology · 2012Review
- Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.Biochemistry. Biokhimiia · 2011Article
- APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers.Biochemical and biophysical research communications · 2010Article
- Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.Nucleic acids research · 2005Article
- Tissue-specific modification of gld-2 mRNA in C. elegans: likely C-to-U editing.RNA (New York, N.Y.) · 2004Article
- The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans.The Biochemical journal · 2002Article
- Comparative genomics and evolution of proteins involved in RNA metabolism.Nucleic acids research · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Yeast co-expressing rat APOBEC-1 and a fragment of human apolipoprotein B (apoB) mRNA assembled functional editosomes and deaminated C6666 to U in a mooring sequence-dependent fashion. The occurrence of APOBEC-1-complementing proteins suggested a naturally occurring mRNA editing mechanism in yeast. Previously, a hidden Markov model identified seven yeast genes encoding proteins possessing putative zinc-dependent deaminase motifs. Here, only CDD1, a cytidine deaminase, is shown to have the capacity to carry out C-->U editing on a reporter mRNA. This is only the second report of a cytidine deaminase that can use mRNA as a substrate. CDD1-dependent editing was growth phase regulated and demonstrated mooring sequence-dependent editing activity. Candidate yeast mRNA substrates were identified based on their homology with the mooring sequence-containing tripartite motif at the editing site of apoB mRNA and their ability to be edited by ectopically expressed APOBEC-1. Naturally occurring yeast mRNAs edited to a significant extent by CDD1 were, however, not detected. We propose that CDD1 be designated an orphan C-->U editase until its native RNA substrate, if any, can be identified and that it be added to the CDAR (cytidine deaminase acting on RNA) family of editing enzymes.
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Registered trials
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