ArticleInfection and immunity2001
Spa contributes to the virulence of type 18 group A streptococci.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers.Pathogens and disease · 2017Article
- Towards developing a vaccine for rheumatic heart disease.Global cardiology science & practice · 2017Review
- Group A streptococcus expresses a trio of surface proteins containing protective epitopes.Clinical and vaccine immunology : CVI · 2014Article
- Tissue tropisms in group A streptococcal infections.Future microbiology · 2010Review
- Streptococcal protective antigens (Spa): a new family of type-specific proteins of group A streptococci.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes.PloS one · 2009Article
- Article
- Serum opacity factor (SOF) of Streptococcus pyogenes evokes antibodies that opsonize homologous and heterologous SOF-positive serotypes of group A streptococci.Infection and immunity · 2003Article
- Antibodies against a synthetic peptide of SagA neutralize the cytolytic activity of streptolysin S from group A streptococci.Infection and immunity · 2002Article
- Differential recognition of surface proteins in Streptococcus pyogenes by two sortase gene homologs.Journal of bacteriology · 2002Article
- Immunogenicity of a 26-valent group A streptococcal vaccine.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcal protective antigen (Spa) is a newly described surface protein of group A streptococci that was recently shown to evoke protective antibodies (J. B. Dale, E. Y. Chiang, S. Liu, H. S. Courtney, and D. L. Hasty, J. Clin. Investig. 103:1261--1268, 1999). In this study, we have determined the complete sequence of the spa gene from type 18 streptococci. Purified, recombinant Spa protein evoked antibodies that were bactericidal against type 18 streptococci, confirming the presence of protective epitopes. Sera from patients with acute rheumatic fever contained antibodies against recombinant Spa, indicating that the Spa protein is expressed in vivo and is immunogenic in humans. To determine the role of Spa in the virulence of group A streptococci, we created a series of insertional mutants that were (i) Spa negative and M18 positive, (ii) Spa positive and M18 negative, and (iii) Spa negative and M18 negative. The mutants and the parent M18 strain (18-282) were used in assays to determine resistance to phagocytosis, growth in human blood, and mouse virulence. The results show that Spa is a virulence determinant of group A streptococci and that expression of both Spa and M18 is required for optimal virulence of type 18 streptococci.
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