ArticleGenetics2001
Genetic and nongenetic bases for the L-shaped distribution of quantitative trait loci effects.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Gene duplication and genetic innovation in cereal genomes.Genome research · 2019Article
- Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence FromFrontiers in genetics · 2018Article
- QTL mapping of domestication and diversifying selection related traits in round-fruited semi-wild Xishuangbanna cucumber (Cucumis sativus L. var. xishuangbannanesis).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Combining powers of linkage and association mapping for precise dissection of QTL controlling resistance to gray leaf spot disease in maize (Zea mays L.).BMC genomics · 2015Article
- A consensus framework map of durum wheat (Triticum durum Desf.) suitable for linkage disequilibrium analysis and genome-wide association mapping.BMC genomics · 2014Article
- The relation between the genetic architecture of quantitative traits and long-term genetic response.Journal of applied genetics · 2014Article
- Simulating local adaptation to climate of forest trees with a Physio-Demo-Genetics model.Evolutionary applications · 2014Article
- The molecular basis of phenotypic variation in yeast.Current opinion in genetics & development · 2013Review
- The many faces of pleiotropy.Trends in genetics : TIG · 2013Article
- Association of 10q23 with colorectal cancer in a Chinese population.Molecular biology reports · 2012Article
- A test for selection employing quantitative trait locus and mutation accumulation data.Genetics · 2012Article
- The QTN program and the alleles that matter for evolution: all that's gold does not glitter.Evolution; international journal of organic evolution · 2012Article
- Bayesian shrinkage analysis of QTLs under shape-adaptive shrinkage priors, and accurate re-estimation of genetic effects.Heredity · 2011Article
- Comprehensive genetic dissection of wood properties in a widely-grown tropical tree: Eucalyptus.BMC genomics · 2011Article
- Replication study of SNP associations for colorectal cancer in Hong Kong Chinese.British journal of cancer · 2011Article
- The evolution of control and distribution of adaptive mutations in a metabolic pathway.Genetics · 2010Article
- Fluctuating selection: the perpetual renewal of adaptation in variable environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- New insights into the aetiology of colorectal cancer from genome-wide association studies.Nature reviews. Genetics · 2009Review
- Molecular and phenotypic characterization of near isogenic lines at QTL for quantitative resistance to Leptosphaeria maculans in oilseed rape (Brassica napus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2008Article
- Precision-mapping and statistical validation of quantitative trait loci by machine learning.BMC genetics · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The L-shaped distribution of estimated QTL effects (R(2)) has long been reported. We recently showed that a metabolic mechanism could account for this phenomenon. But other nonexclusive genetic or nongenetic causes may contribute to generate such a distribution. Using analysis and simulations of an additive genetic model, we show that linkage disequilibrium between QTL, low heritability, and small population size may also be involved, regardless of the gene effect distribution. In addition, a comparison of the additive and metabolic genetic models revealed that estimates of the QTL effects for traits proportional to metabolic flux are far less robust than for additive traits. However, in both models the highest R(2)'s repeatedly correspond to the same set of QTL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.