ArticleGenetics2001
Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 87 citations in OpenAlex.
- Balanced Polymorphism at theGenes · 2022Article
- Patterns of transposable element variation and clinality in Drosophila.Molecular ecology · 2019Article
- Population Genetic and Functional Analysis of aGenes · 2019Article
- Parallel clinal variation in the mid-day siesta of Drosophila melanogaster implicates continent-specific targets of natural selection.PLoS genetics · 2018Article
- Adaptations in energy metabolism and gene family expansions revealed by comparative transcriptomics of three Chagas disease triatomine vectors.BMC genomics · 2018Article
- On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.Scientific reports · 2017Article
- Global Transcriptional Profiling of Diapause and Climatic Adaptation in Drosophila melanogaster.Molecular biology and evolution · 2016Article
- Comparative population genomics of latitudinal variation in Drosophila simulans and Drosophila melanogaster.Molecular ecology · 2016Article
- Seasonal variation in life history traits in two Drosophila species.Journal of evolutionary biology · 2015Article
- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
- Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect of temperature in Drosophila.Genetics · 2013Article
- A genetic polymorphism evolving in parallel in two cell compartments and in two clades.BMC evolutionary biology · 2013Article
- Article
- Natural variation in the Drosophila melanogaster clock gene period modulates splicing of its 3'-terminal intron and mid-day siesta.PloS one · 2012Article
- Adaptations to climate-mediated selective pressures in humans.PLoS genetics · 2011Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
- Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolution.Methods in molecular biology (Clifton, N.J.) · 2011Review
- Whole-genome expression plasticity across tropical and temperate Drosophila melanogaster populations from Eastern Australia.Molecular biology and evolution · 2011Article
- Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.BMC evolutionary biology · 2010Article
- Global depression in gene expression as a response to rapid thermal changes in vent mussels.Proceedings. Biological sciences · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Clinal variation is common for enzymes in the glycolytic pathway for Drosophila melanogaster and is generally accepted as an adaptive response to different climates. Although the enzyme phosphoglucomutase (PGM) possesses several allozyme polymorphisms, it is unique in that it had been reported to show no clinal variation. Our recent DNA sequence investigation of Pgm found extensive cryptic amino acid polymorphism segregating with the allozyme alleles. In this study, we characterize the geographic variation of Pgm amino acid polymorphisms at the nucleotide level along a latitudinal cline in the eastern United States. A survey of 15 SNPs across the Pgm gene finds significant clinal differentiation for the allozyme polymorphisms as well as for many of the cryptic amino acid polymorphisms. A test of independence shows that pervasive linkage disequilibrium across this gene region can explain many of the amino acid clines. A single Pgm haplotype defined by two amino acid polymorphisms shows the strongest correlation with latitude and the steepest change in allele frequency across the cline. We propose that clinal selection at Pgm may in part explain the extensive amino acid polymorphism at this locus and is consistent with a multilocus response to selection in the glycolytic pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.