ArticleGenetics2001
Identification of chromosome inheritance modifiers in Drosophila melanogaster.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Long-term in vivo imaging of Drosophila larvae.Nature protocols · 2020Article
- Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis.Human cell · 2018Article
- TAT-mediated si-hWAPL inhibits the invasion and metastasis of cervical cancer stem cells.Experimental and therapeutic medicine · 2017Article
- Human wings apart-like gene is specifically overexpressed in cervical cancer.Oncology letters · 2016Article
- Achiasmy: Male Fruit Flies Are Not Ready to Mix.Frontiers in cell and developmental biology · 2016Article
- Identification and functional analysis of healing regulators in Drosophila.PLoS genetics · 2015Article
- Relationship between hWAPL polymorphisms and cervical cancer susceptibility.International journal of clinical and experimental pathology · 2015Article
- Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles.Genetics · 2010Article
- Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling.Cellular and molecular life sciences : CMLS · 2010Review
- Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.Genes & development · 2009Article
- Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage.Molecular cell · 2009Article
- Article
- On the molecular etiology of Cornelia de Lange syndrome.Annals of the New York Academy of Sciences · 2009Review
- Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.Chromosoma · 2008Article
- Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans.PLoS biology · 2007Article
- Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1.Molecular biology of the cell · 2007Article
- Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.Current biology : CB · 2006Article
- A high proportion of genes involved in position effect variegation also affect chromosome inheritance.Chromosoma · 2004Article
- Genetics of P-element transposition into Drosophila melanogaster centric heterochromatin.Genetics · 2003Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Faithful chromosome inheritance is a fundamental biological activity and errors contribute to birth defects and cancer progression. We have performed a P-element screen in Drosophila melanogaster with the aim of identifying novel candidate genes involved in inheritance. We used a "sensitized" minichromosome substrate (J21A) to screen approximately 3,000 new P-element lines for dominant effects on chromosome inheritance and recovered 78 Sensitized chromosome inheritance modifiers (Scim). Of these, 69 decreased minichromosome inheritance while 9 increased minichromosome inheritance. Fourteen mutations are lethal or semilethal when homozygous and all exhibit dramatic mitotic defects. Inverse PCR combined with genomic analyses identified P insertions within or close to genes with previously described inheritance functions, including wings apart-like (wapl), centrosomin (cnn), and pavarotti (pav). Further, lethal insertions in replication factor complex 4 (rfc4) and GTPase-activating protein 1 (Gap1) exhibit specific mitotic chromosome defects, discovering previously unknown roles for these proteins in chromosome inheritance. The majority of the lines represent mutations in previously uncharacterized loci, many of which have human homologs, and we anticipate that this collection will provide a rich source of mutations in new genes required for chromosome inheritance in metazoans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.