ArticleGenetics2001
Isolation and characterization of WHI3, a size-control gene of Saccharomyces cerevisiae.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed.
- Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Investigating the role of RNA-binding protein Ssd1 in aneuploidy tolerance through network analysis.RNA (New York, N.Y.) · 2024Article
- Subscaling of a cytosolic RNA binding protein governs cell size homeostasis in the multiple fission alga Chlamydomonas.PLoS genetics · 2024Article
- Hyperactive Ras disrupts cell size control and a key step in cell cycle entry in budding yeast.Genetics · 2023Article
- The functional study of human proteins using humanized yeast.Journal of microbiology (Seoul, Korea) · 2020Review
- Differential Scaling of Gene Expression with Cell Size May Explain Size Control in Budding Yeast.Molecular cell · 2020Article
- Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community.eLife · 2019Article
- Nuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume.Molecular biology of the cell · 2019Article
- A Visual Framework for Classifying Determinants of Cell Size.Cell reports · 2018Article
- Whi2 signals low leucine availability to halt yeast growth and cell death.FEMS yeast research · 2018Review
- mRNA structure determines specificity of a polyQ-driven phase separation.Science (New York, N.Y.) · 2018Article
- Growth Rate as a Direct Regulator of the Start Network to Set Cell Size.Frontiers in cell and developmental biology · 2017Review
- The non-homologous end-joining pathway of S. cerevisiae works effectively in G1-phase cells, and religates cognate ends correctly and non-randomly.DNA repair · 2016Article
- Experimental testing of a new integrated model of the budding yeast Start transition.Molecular biology of the cell · 2015Article
- RNA Controls PolyQ Protein Phase Transitions.Molecular cell · 2015Article
- Chromosome length and perinuclear attachment constrain resolution of DNA intertwines.The Journal of cell biology · 2014Article
- Nuclear repulsion enables division autonomy in a single cytoplasm.Current biology : CB · 2013Article
- The RNA-binding protein Whi3 is a key regulator of developmental signaling and ploidy in Saccharomyces cerevisiae.Genetics · 2013Article
- Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control.Developmental cell · 2013Article
- Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
WHI3 is a gene affecting size control and cell cycle in the yeast Saccharomyces cerevisiae. The whi3 mutant has small cells, while extra doses of WHI3 produce large cells, and a large excess of WHI3 produces a lethal arrest in G1 phase. WHI3 seems to be a dose-dependent inhibitor of Start. Whi3 and its partially redundant homolog Whi4 have an RNA-binding domain, and mutagenesis experiments indicate that this RNA-binding domain is essential for Whi3 function. CLN3-1 whi3 cells are extremely small, nearly sterile, and largely nonresponsive to mating factor. Fertility is restored by deletion of CLN2, suggesting that whi3 cells may have abnormally high levels of CLN2 function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.