ArticleThe American journal of pathology2001
Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 130 citations in OpenAlex.
- Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients.Annals of surgical oncology · 2011Trial
- Chromosomal instability: a key driver in glioma pathogenesis and progression.European journal of medical research · 2024Review
- Novel insights on genetics and epigenetics as clinical targets for paediatric astrocytoma.Clinical and translational medicine · 2024Review
- Review
- High Grade Glioma Treatment in Elderly People: Is It Different Than in Younger Patients? Analysis of Surgical Management Guided by an Intraoperative Multimodal Approach and Its Impact on Clinical Outcome.Frontiers in oncology · 2020Article
- Evaluating extent of resection in pediatric glioblastoma: a multiple propensity score-adjusted population-based analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity.Brain pathology (Zurich, Switzerland) · 2015Article
- Epidemiologic and molecular prognostic review of glioblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Review
- Reductions in the expression of miR-124-3p, miR-128-1, and miR-221-3p in pediatric astrocytomas are related to high-grade supratentorial, and recurrent tumors in Mexican children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Histologically proven, low-grade brainstem gliomas in children: 30-year experience with long-term follow-up at Mayo Clinic.American journal of clinical oncology · 2014Article
- Arterial spin-labeled perfusion of pediatric brain tumors.AJNR. American journal of neuroradiology · 2014Article
- Genome-wide copy number analysis in pediatric glioblastoma multiforme.American journal of cancer research · 2014Article
- Adult cerebellar glioblastoma: understanding survival and prognostic factors using a population-based database from 1973 to 2009.World neurosurgery · 2013Article
- A new prognostic scoring scale for patients with primary WHO grade III gliomas based on molecular predictors.Journal of neuro-oncology · 2013Article
- Pediatric high grade glioma: a review and update on tumor clinical characteristics and biology.Frontiers in oncology · 2012Article
- Deregulation of ion channel and transporter encoding genes in pediatric gliomas.Frontiers in oncology · 2012Article
- Biology, genetics and imaging of glial cell tumours.The British journal of radiology · 2011Review
- The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival.Neurological research · 2011Article
- Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. Clinical article.Journal of neurosurgery · 2011Article
- Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas.Neuro-oncology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied 23 pediatric high-grade astrocytomas by comparative genomic hybridization. Chromosomal imbalances were found in 10 of 10 anaplastic astrocytomas and 11 of 13 glioblastomas and consisted of +1q (43%), +3q (26%), +1p, +2q, +5q (22%), -22q (34%), -6q, -10q (30%), -9q, -11q, -13q, -16q, and -17p (22%). Anaplastic astrocytomas frequently showed +5q (40%), +1q (30%), -22q (50%), -6q, -9q (40%), and -12q (30%); glioblastomas +1q (54%), +3q (38%), +2q, +17q (23%), -6q, -8q, -10q, -13q, and -17p (31%). Minimal common regions mapped to +1q21-41, +3q27-qter, +2q31-32, +5q14-22, -22q12-qter, -10q23-25, -6q25-qter, -9q34.2, -11q14-22, -16q22-qter, and -17p. High-level gains were located on 1q (7 cases), 2q, 7q (4 cases), 3q (3 cases), 9, 17q (2 cases), 4q, 8q, 18, and 20q (1 case). A significantly shorter survival was found for anaplastic astrocytomas showing +1q (P: < 0.05), MIB-1 proliferation index >25% (P: < 0.001) and glioblastomas (P: < 0.05). Compared with adult cases, +1p, +2q, and +21q as well as -6q, -11q, and -16q were more frequent in pediatric malignant astrocytomas. Among the latter +5q, -6q, -9q, -12q, and -22q were characteristic for pediatric anaplastic astrocytomas and +1q, +3q, +16p, -8q, and -17p for pediatric glioblastomas. Our results show that chromosomal aberrations differ between pediatric anaplastic astrocytomas and glioblastomas as well as between pediatric and adult high-grade astrocytomas, supporting the notion of a different genetic pathway. Furthermore, gains of chromosomal material on 1q might be correlated with a worse prognosis in pediatric anaplastic astrocytomas.
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