ArticleThe American journal of pathology2001
Elevated proportion of natural killer T cells in periodontitis lesions: a common feature of chronic inflammatory diseases.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature.International journal of molecular sciences · 2020Pooled it
- Cytokine responses of CD4+ T cells and NKT cells to periodontitis-associated bacteria in individuals with or without periodontitis.Journal of periodontal research · 2025Article
- Article
- Maintaining homeostatic control of periodontal bone tissue.Periodontology 2000 · 2021Review
- Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells.Mediators of inflammation · 2021Review
- The influence ofCentral-European journal of immunology · 2017Article
- Langerhans cells down-regulate inflammation-driven alveolar bone loss.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Natural killer T cells: innate lymphocytes positioned as a bridge between acute and chronic inflammation?Microbes and infection · 2010Review
- Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining.The Journal of experimental medicine · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although periodontitis is a chronic inflammatory disease caused by a group of so-called periodontopathic bacteria, autoimmune mechanisms have also been implicated in the disease process. Recently, a unique subset of lymphocytes designated natural killer (NK) T cells expressing the Valpha24JalphaQ invariant T cell receptor (TCR) has been reported to have a regulatory role in certain autoimmune diseases. Therefore, we investigated the proportion of the invariant Valpha24JalphaQ TCR within the Valpha24 T cell population in periodontitis lesions and gingivitis lesions using single-strand conformation polymorphism methodology. NK T cells were identified with a specific JalphaQ probe whereas the total Valpha24 TCR was identified using an internal Calpha probe. NK T cells were a significant proportion of the total Valpha24 population both in periodontitis lesions and to a lesser extent in gingivitis lesions but not in the peripheral blood of either periodontitis patients or nondiseased controls. Using immunohistochemistry, some of Valpha24(+) cells in the periodontitis lesions seemed to associate with CD1d(+) cells, which are specific antigen-presenting cells for NK T cells. Although the mechanism underlying the elevation of NK T cells in periodontitis and in gingivitis lesions remains unclear, it can be postulated that NK T cells are recruited to a play regulatory role in the immune response to bacterial infection.
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Registered trials
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