ArticleThe American journal of pathology2001
Origin and structural evolution of the early proliferating oval cells in rat liver.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 279 citations in OpenAlex.
- Microenvironmental control of the ductular reaction: balancing repair and disease progression.Cell death & disease · 2025Review
- Bipotent transitional liver progenitor cells contribute to liver regeneration.Nature genetics · 2023Article
- Hepatocyte generation in liver homeostasis, repair, and regeneration.Cell regeneration (London, England) · 2022Review
- Role of Immune Cells in Biliary Repair.Frontiers in immunology · 2022Review
- Article
- Hepatic stellate cells contribute to liver regeneration through galectins in hepatic stem cell niche.Stem cell research & therapy · 2020Article
- Innervation of the proximal human biliary tree.Virchows Archiv : an international journal of pathology · 2020Article
- Postnatal, ontogenic liver growth accomplished by biliary/oval cell proliferation and differentiation.PloS one · 2020Article
- Vector-free in vivo trans-determination of adult hepatic stem cells to insulin-producing cells.Molecular biology reports · 2019Article
- Liver stem cells: Plasticity of the liver epithelium.World journal of gastroenterology · 2019Review
- Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish.Gene expression · 2018Article
- Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.Stem cell reports · 2017Article
- Fn14 hepatic progenitor cells are associated with liver fibrosis in biliary atresia.Pediatric surgery international · 2017Article
- Ultrastructural Characteristics of Rat Hepatic Oval Cells and Their Intercellular Contacts in the Model of Biliary Fibrosis: New Insights into Experimental Liver Fibrogenesis.Gastroenterology research and practice · 2017Article
- Protective roles of hepatic GABA signaling in liver injury.International journal of physiology, pathophysiology and pharmacology · 2017Article
- Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.PloS one · 2017Article
- Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury.Scientific reports · 2016Article
- Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration.Journal of visualized experiments : JoVE · 2016Article
- Stem cells versus plasticity in liver and pancreas regeneration.Nature cell biology · 2016Review
- Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells.Stem cells international · 2016Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analyzed the histological changes in rat liver after 2-acetylaminofluorene (AAF) administration. The data demonstrate that AAF-induced oval cells were preferentially generated by proliferation of the terminal biliary ductules that we suggest constitute the primary hepatic stem cell niche. The oval cells formed ductular structures, representing an extension of the canals of Hering. This histological organization provides continuous bile drainage of the hepatocytes and uninterrupted blood flow in the sinusoids. The oval cell ductules are surrounded by a continuous basement membrane that is intermittently disrupted by processes of stellate cells that form direct cell-cell contact with the oval cells. Although both AAF treatment and bile duct ligation results in proliferation of biliary epithelial cells, the mechanism(s) responsible for the proliferation of the biliary epithelium seems to differ in the two models. In contrast to the biliary proliferation stimulated by bile ligation, AAF-induced oval cell proliferation as well as the capacity of these cells to differentiate into hepatocytes, bile epithelial cells and possibly other cell lineages can be blocked by administration of dexamethasone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.