ArticleThe American journal of pathology2001
Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 102 citations in OpenAlex.
- Female hormones enhance skin T cell expansion and suppress IFN-γ production.Frontiers in immunology · 2026Article
- Integrative transcriptomic analysis identifies CCL22-associated immune signatures in air pollution-related atopic dermatitis.Frontiers in public health · 2026Article
- Antisense molecules: A promising new therapy for atopic dermatitis.Acta pharmaceutica Sinica. B · 2025Review
- Jing Guan Fang, an herbal formula, as an immunomodulator: opposing effects on basal and lipopolysaccharide-induced inflammation of macrophage via JAK/STAT3 and MAPK pathways.Frontiers in pharmacology · 2025Article
- Topical application of a CCL22-binding aptamer suppresses contact allergy.Molecular therapy. Nucleic acids · 2024Article
- Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.The Journal of experimental medicine · 2020Article
- T-cell positioning by chemokines in autoimmune skin diseases.Immunological reviews · 2019Review
- Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.The American journal of pathology · 2016Article
- Inducible lymphoid clusters, iSALTs, in contact dermatitis: a new concept of acquired cutaneous immune responses.Medical molecular morphology · 2016Review
- Skin DCs cluster for efficient T cell activation.Nature immunology · 2014Article
- Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure.The American journal of pathology · 2014Article
- The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin.Annual review of pathology · 2013Review
- CC chemokine receptor 4 contributes to innate NK and chronic stage T helper cell recall responses during Mycobacterium bovis infection.The American journal of pathology · 2011Article
- Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.Nature immunology · 2010Article
- Article
- Modeling lymphocyte homing and encounters in lymph nodes.BMC bioinformatics · 2009Article
- Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.Histopathology · 2009Article
- Differential CCR4 expression and function in cutaneous T-cell lymphoma cell lines.The Kaohsiung journal of medical sciences · 2008Article
- In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous study demonstrated formation of T cell-dendritic cell (DC) clusters in inflamed dermis of intraorally autotransplanted skin flaps. Such T cell-DC clusters are supposed to be important for close interactions between T cells and DCs including the specific antigen presentation. Here we show the involvement of the macrophage-derived chemokine (MDC/CCL22) and its specific receptor CC chemokine receptor 4 (CCR4) in the formation of T cell-DC clusters. Reverse transcriptase-polymerase chain reaction analysis revealed high levels of mRNA expression for MDC and CCR4 in inflamed skin and neck lymph nodes (LNs), but not in normal skin. Immunohistochemically, MDC(+) cells and CCR4(+) cells were mainly located within the T cell-DC clusters both in the dermis of inflamed skin and the T cell area of LNs. MDC(+) cells were identified to be DCs both in inflamed skin and LNs. The majority of CCR4(+) cells were CD4(+) T cells, accounting for approximately one-third of total CD4(+) T cells in the inflamed skin. Our data suggest that the MDC-CCR4 system plays an important role in the formation of T cell-DC clusters both in inflamed skin and LNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.