ArticleThe American journal of pathology2001
Comparative genome-scale analysis of gene expression profiles in T cell lymphoma cells during malignant progression using a complementary DNA microarray.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 61 citations in OpenAlex.
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- High soluble CD30, CD25, and IL-6 may identify patients with worse survival in CD30+ cutaneous lymphomas and early mycosis fungoides.The Journal of investigative dermatology · 2012Article
- The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma.International journal of oncology · 2011Article
- Reduced mitochondrial properties in putative progenitor/stem cells of human keratinocytes.Annals of dermatology · 2009Article
- Early indicators of exposure to biological threat agents using host gene profiles in peripheral blood mononuclear cells.BMC infectious diseases · 2008Article
- Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas.Oncogene · 2006Article
- The application of immunohistochemistry in the diagnosis of bone tumors and tumor-like lesions.Skeletal radiology · 2005Review
- An Activated GOPS-poly-Engineering in life sciences · 2005Article
- Article
- Validation of cDNA microarray gene expression data obtained from linearly amplified RNA.Molecular pathology : MP · 2003Article
- Microarray analysis of B-cell lymphoma cell lines with the t(14;18).The Journal of molecular diagnostics : JMD · 2002Article
- Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Using a cDNA microarray, we compared the expression of approximately 8000 genes between two unique, clonally related T cell lines derived from different stages of a progressive T cell lymphoma involving skin. A total of 180 genes was found to be differentially expressed at the RNA level by a factor of fivefold or greater. Compared with the cells from the earlier, clinically indolent stage of the lymphoma, 56 genes were up-regulated, whereas 124 genes were down-regulated in the cells from the advanced, clinically aggressive stage lymphoma. The functions of approximately 65% of these genes are currently unknown. The 22 genes with a known function that were up-regulated in the advanced lymphoma cells included several genes involved in promotion of cell proliferation and survival as well as drug resistance. The 42 functionally characterized genes that were down-regulated in the advanced lymphoma cells included negative regulators of cell activation and cell cycle, and mediators of cell adhesion, apoptosis, and genome integrity. The differential expression identified by the cDNA microarray analysis was confirmed for selected genes by reverse transcription-polymerase chain reaction and Northern blotting. The identified differences in gene expression may be related to the differences in behavior between the early and advanced stages of the T cell lymphoma and point to directions for further investigations into mechanisms of lymphoma progression.
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