ArticleAJNR. American journal of neuroradiology2001
Enhancing patterns in multiple sclerosis: evolution and persistence.
Article in AJNR. American journal of neuroradiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MRI Findings in Tumefactive Demyelinating Lesions: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Cerebral enhancement in MOG antibody-associated disease.Journal of neurology, neurosurgery, and psychiatry · 2023Observational
- AI-based detection of contrast-enhancing MRI lesions in patients with multiple sclerosis.Insights into imaging · 2023Article
- Evolution of acute "black hole" lesions in patients with relapsing-remitting multiple sclerosis.Acta neurologica Belgica · 2023Observational
- Clinical spectrum and prognosis of pathologically confirmed atypical tumefactive demyelinating lesions.Scientific reports · 2023Article
- TowardBiosensors · 2022Review
- MRI predictors for the conversion from contrast-enhancing to iron rim multiple sclerosis lesions.Journal of neurology · 2022Article
- In Vivo Proton Exchange Rate (kJournal of magnetic resonance imaging : JMRI · 2021Article
- High-b diffusivity of MS lesions in cervical spinal cord using ultrahigh-b DWI (UHb-DWI).NeuroImage. Clinical · 2021Article
- Growth differentiation factor 15 is increased in stable MS.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Gadolinium-Enhanced Susceptibility-Weighted Imaging in Multiple Sclerosis: Optimizing the Recognition of Active Plaques for Different MR Imaging Sequences.AJNR. American journal of neuroradiology · 2019Observational
- Quantifying the Metabolic Signature of Multiple Sclerosis byFrontiers in neurology · 2019Review
- Inaugural tumor-like multiple sclerosis: clinical presentation and medium-term outcome in 87 patients.Journal of neurology · 2018Article
- Transtentorial herniation from tumefactive multiple sclerosis mimicking primary brain tumor.Surgical neurology international · 2018Article
- Article
- Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society.Acta neurologica Scandinavica · 2017Review
- Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation.AJNR. American journal of neuroradiology · 2016Article
- Demyelination as a harbinger of lymphoma: a case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination.BMC neurology · 2016Article
- Albumin and multiple sclerosis.BMC neurology · 2016Review
- Cerebral tumefactive demyelinating lesions.Oncology letters · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
background and purposeContrast enhancement on MR images of patients with multiple sclerosis (MS) is known to be associated with abnormalities of the blood-brain barrier (BBB). However, little is known about diagnostic patterns and common features of enhanced MS lesions. This study was designed to evaluate initial enhancement patterns, changes in these enhancing patterns, and duration of enhancement in a cohort of patients with MS.
methodsTwenty-five patients with clinically definite MS were studied retrospectively. The appearance of enhancing lesions and sequential changes in the appearance on axial contrast-enhanced spin-echo images were evaluated. The enhancing lesions were classified as nodular, ringlike, or "other" (eg, arclike).
resultsOf 301 new enhancing lesions, 205 (68%) showed nodular enhancement, 70 (23%) a ring pattern, and 26 (9%) a pattern neither nodular nor ringlike (eg, arclike). Two hundred eighty (93%) of 301 enhancing lesions disappeared within 6 months, and seven (2%) lesions showed persistent enhancement longer than 6 months. The other 14 (5%) lesions, which disappeared by the time of the next scan, were excluded, because the course between two examinations was longer than 6 months. Of nine persisting nodular enhancing lesions on the follow-up images, seven were decreased in size, whereas all of two persisting ringlike enhancing lesions on the follow-up images were larger than before.
conclusionNodular enhancement is the predominant enhancement pattern for new MS lesions, and the temporal course of enhancement is usually shorter than 6 months. The appreciation of the evolution of MS-enhanced lesions aids in both identifying new MS lesions and distinguishing these lesions from other pathologic entities. This may be helpful in clinically evaluating the stage of MS lesions.
Indexed as
Identifiers
11290475PMC7976005What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.