ArticleProceedings of the National Academy of Sciences of the United States of America2001
Proteomic analysis of the bacterial cell cycle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Rif-seq reveals Caulobacter crescentus mRNA decay is globally coordinated with transcription and translation.Cell reports · 2025Article
- Computational modeling of unphosphorylated CtrA:iScience · 2021Article
- Article
- Cysteine Proteome Reveals Response to Endogenous Oxidative Stress inInternational journal of molecular sciences · 2021Article
- Dynamic control over feedback regulatory mechanisms improves NADPH flux and xylitol biosynthesis in engineered E. coli.Metabolic engineering · 2021Article
- The Protein Quality Control Network inFrontiers in molecular biosciences · 2021Review
- Using optimal control to understand complex metabolic pathways.BMC bioinformatics · 2020Article
- Untargeted metabolomics links glutathione to bacterial cell cycle progression.Nature metabolism · 2020Article
- Inducible asymmetric cell division and cell differentiation in a bacterium.Nature chemical biology · 2019Article
- Absolute Measurements of mRNA Translation in Caulobacter crescentus Reveal Important Fitness Costs of Vitamin BmSystems · 2019Article
- Polar Localization Hub Protein PopZ Restrains Adaptor-Dependent ClpXP Proteolysis in Caulobacter crescentus.Journal of bacteriology · 2018Article
- Sizing up the bacterial cell cycle.Nature reviews. Microbiology · 2017Review
- A Spatial Control for Correct Timing of Gene Expression during the Escherichia coli Cell Cycle.Genes · 2016Article
- Regulated Proteolysis in Bacteria: Caulobacter.Annual review of genetics · 2016Review
- Temporal and intrinsic factors of rifampicin tolerance in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CauloBrowser: A systems biology resource for Caulobacter crescentus.Nucleic acids research · 2016Article
- Nutritional Control of DNA Replication Initiation through the Proteolysis and Regulated Translation of DnaA.PLoS genetics · 2015Article
- Identification of ClpP substrates in Caulobacter crescentus reveals a role for regulated proteolysis in bacterial development.Molecular microbiology · 2013Article
- Quantitative proteomic analysis of cell cycle of the dinoflagellate Prorocentrum donghaiense (Dinophyceae).PloS one · 2013Article
- Transcriptome and proteome dynamics of a light-dark synchronized bacterial cell cycle.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A global approach was used to analyze protein synthesis and stability during the cell cycle of the bacterium Caulobacter crescentus. Approximately one-fourth (979) of the estimated C. crescentus gene products were detected by two-dimensional gel electrophoresis, 144 of which showed differential cell cycle expression patterns. Eighty-one of these proteins were identified by mass spectrometry and were assigned to a wide variety of functional groups. Pattern analysis revealed that coexpression groups were functionally clustered. A total of 48 proteins were rapidly degraded in the course of one cell cycle. More than half of these unstable proteins were also found to be synthesized in a cell cycle-dependent manner, establishing a strong correlation between rapid protein turnover and the periodicity of the bacterial cell cycle. This is, to our knowledge, the first evidence for a global role of proteolysis in bacterial cell cycle control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.