ArticleMolecular and cellular biology2001
Role of NF-Y in in vivo regulation of the gamma-globin gene.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Review
- Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.Nature genetics · 2021Article
- Transcription factor competition at the γ-globin promoters controls hemoglobin switching.Nature genetics · 2021Article
- Article
- Article
- Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.Genome medicine · 2015Article
- The chromatin-binding protein HMGN3 stimulates histone acetylation and transcription across the Glyt1 gene.The Biochemical journal · 2012Article
- Article
- Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.PloS one · 2011Article
- Role of STAT3 and GATA-1 interactions in gamma-globin gene expression.Experimental hematology · 2009Article
- SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.Blood · 2009Article
- Nuclear factor Y is required for basal activation and chromatin accessibility of fibroblast growth factor receptor 2 promoter in osteoblast-like cells.The Journal of biological chemistry · 2009Article
- The cHS4 chromatin insulator reduces gammaretroviral vector silencing by epigenetic modifications of integrated provirus.Gene therapy · 2008Article
- Article
- Purification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoter.The Journal of biological chemistry · 2007Article
- Fine tuning of globin gene expression by DNA methylation.PloS one · 2006Article
- Antagonistic regulation of beta-globin gene expression by helix-loop-helix proteins USF and TFII-I.Molecular and cellular biology · 2006Article
- Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters.Nucleic acids research · 2006Article
- A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.Genes & development · 2005Article
- NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The duplicated CCAAT box is required for gamma gene expression. We report here that the transcriptional factor NF-Y is recruited to the duplicated CCAAT box in vivo. A mutation of the duplicated CCAAT box that severely disrupts the NF-Y binding also reduces the accessibility level of the gamma gene promoter, affects the assembly of basal transcriptional machinery, and increases the recruitment of GATA-1 to the locus control region (LCR) and the proximal promoter and the recruitment of transcription cofactor CBP/p300 to the LCR. These findings suggest that recruitment of NF-Y to the duplicated CCAAT box plays a role in the chromatin opening of the gamma gene promoter as well as in the communication between the gamma gene promoter and the LCR.
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