ArticleMolecular and cellular biology2001
Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
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- Mechanisms of Binding Specificity among bHLH Transcription Factors.International journal of molecular sciences · 2021Review
- Tissue-specific changes inEnvironmental epigenetics · 2019Article
- TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis.In vitro cellular & developmental biology. Animal · 2016Article
- Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.Nucleic acids research · 2013Article
- Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.PloS one · 2013Article
- Notch signalling inhibits CD4 expression during initiation and differentiation of human T cell lineage.PloS one · 2012Article
- B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers.Nature immunology · 2010Article
- Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.Nature reviews. Immunology · 2008Review
- Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation.The Journal of biological chemistry · 2008Article
- Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.The EMBO journal · 2007Article
- ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer.Journal of virology · 2007Article
- Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors.Nucleic acids research · 2007Review
- Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1.Molecular and cellular biology · 2005Article
- Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.The EMBO journal · 2003Article
- The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes.The Journal of experimental medicine · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of the CD4 gene is tightly controlled throughout thymopoiesis. The downregulation of CD4 gene expression in CD4(-) CD8(-) and CD4(-) CD8(+) T lymphocytes is controlled by a transcriptional silencer located in the first intron of the CD4 locus. Here, we determine that the c-Myb transcription factor binds to a functional site in the CD4 silencer. As c-Myb is also required for CD4 promoter function, these data indicate that depending on the context, c-Myb plays both positive and negative roles in the control of CD4 gene expression. Interestingly, a second CD4 silencer-binding factor, HES-1, binds to c-Myb in vivo and induces it to become a transcriptional repressor. We propose that the recruitment of HES-1 and c-Myb to the silencer leads to the formation of a multifactor complex that induces silencer function and repression of CD4 gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.