ArticleMolecular and cellular biology2001
AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
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- New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets.International journal of biological sciences · 2025Review
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- Recent Developments in Using Microneedle Patch Technology as a More Efficient Drug Delivery System for Treating Skin Photoaging.Clinical, cosmetic and investigational dermatology · 2024Review
- Strategies for Improving Photodynamic Therapy Through Pharmacological Modulation of the Immediate Early Stress Response.Methods in molecular biology (Clifton, N.J.) · 2022Review
- An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease.Nature genetics · 2020Article
- Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics.Frontiers in oncology · 2019Review
- Estrogen receptor signaling mechanisms.Advances in protein chemistry and structural biology · 2019Review
- Jun dimerization protein 2 controls hypoxia-induced replicative senescence via both the p16FEBS open bio · 2017Article
- Review
- Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.PLoS genetics · 2016Article
- The oncogene c-Jun impedes somatic cell reprogramming.Nature cell biology · 2015Article
- Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis.Oncotarget · 2013Article
- Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity.Oncogene · 2013Article
- JDP2 inhibits the epithelial-to-mesenchymal transition in pancreatic cancer BxPC3 cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.The Journal of biological chemistry · 2011Article
- Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification.Journal of biomedicine & biotechnology · 2011Review
- Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2.Oncogene · 2010Article
- Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging.The Kaohsiung journal of medical sciences · 2010Review
- The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice.Molecular cancer · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the AP-1 transcription factor family, especially c-Jun and c-Fos, have long been known to mediate critical steps in the cellular response to ultraviolet (UV) irradiation. We sought to examine whether two newly discovered members of the AP-1 family, JDP-1 and JDP-2, also participate in the mammalian UV response. Here we report that JDP-2, but not JDP-1, is transiently induced upon UV challenge and that elevated levels of JDP-2 increase cell survival following UV exposure. This protective function of JDP-2 appears to be mediated through repression of p53 expression at the transcriptional level, via a conserved atypical AP-1 site in the p53 promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.