ArticleJournal of virology2001
Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 118 citations in OpenAlex.
- Transcriptomic insights into early responses of the uterovaginal junction and vagina to avian influenza virus infection in turkey breeder hens.Frontiers in physiology · 2025Article
- Pathway expression analysis.Scientific reports · 2022Article
- Attenuated Viral Replication of AvianMicrobiology spectrum · 2022Article
- Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells.Scientific reports · 2022Article
- The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense.Annual review of immunology · 2021Article
- HLA-associated protection of lymphocytes during influenza virus infection.Virology journal · 2020Article
- Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus InfectionJournal of virology · 2019Article
- H9N2 Viruses Isolated From Mammals Replicated in Mice at Higher Levels Than Avian-Origin Viruses.Frontiers in microbiology · 2019Article
- Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway.Virology journal · 2018Article
- Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines.Functional & integrative genomics · 2018Article
- Controlled detonation: evolution of necroptosis in pathogen defense.Immunology and cell biology · 2017Review
- Article
- Human microRNAs profiling in response to influenza A viruses (subtypes pH1N1, H3N2, and H5N1).Experimental biology and medicine (Maywood, N.J.) · 2016Article
- The N terminus of the influenza B virus nucleoprotein is essential for virus viability, nuclear localization, and optimal transcription and replication of the viral genome.Journal of virology · 2014Article
- Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.Seminars in immunology · 2013Review
- Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis.Journal of virology · 2013Article
- Permissive and restricted virus infection of murine embryonic stem cells.The Journal of general virology · 2012Article
- Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition.Veterinary research · 2012Article
- Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Review
- Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.The EMBO journal · 2011Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Influenza virus, the causative agent of the common flu, is a worldwide health problem with significant economic consequences. Studies of influenza virus biology have revealed elaborate mechanisms by which the virus interacts with its host cell as it inhibits the synthesis of cellular proteins, evades the innate antiviral response, and facilitates production of viral RNAs and proteins. With the advent of DNA array technology it is now possible to obtain a large-scale view of how viruses alter the environment within the host cell. In this study, the cellular response to influenza virus infection was examined by monitoring the steady-state mRNA levels for over 4,600 cellular genes. Infections with active and inactivated influenza viruses identified changes in cellular gene expression that were dependent on or independent of viral replication, respectively. Viral replication resulted in the downregulation of many cellular mRNAs, and the effect was enhanced with time postinfection. Interestingly, several genes involved in protein synthesis, transcriptional regulation, and cytokine signaling were induced by influenza virus replication, suggesting that some may play essential or accessory roles in the viral life cycle or the host cell's stress response. The gene expression pattern induced by inactivated viruses revealed induction of the cellular metallothionein genes that may represent a protective response to virus-induced oxidative stress. Genome-scale analyses of virus infections will help us to understand the complexities of virus-host interactions and may lead to the discovery of novel drug targets or antiviral therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.