ArticleJournal of virology2001
Regulation of human immunodeficiency virus type 1 infection, beta-chemokine production, and CCR5 expression in CD40L-stimulated macrophages: immune control of viral entry.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Pannexin-1 channels, extracellular ATP, and purinergic receptors are essential for CCR5/CXCR4 clustering and HIV entry.NeuroImmune pharmacology and therapeutics · 2025Article
- Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV.Results and problems in cell differentiation · 2024Review
- Cytomegalovirus, Macrophages and Breast Cancer.The open virology journal · 2017Review
- Article
- Mucosal correlates of protection in HIV-1-exposed sero-negative persons.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65.Nucleic acids research · 2012Article
- Regulation of inflammatory pathways in cancer and infectious disease of the cervix.Scientifica · 2012Review
- Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines.Retrovirology · 2011Article
- Macrophage signaling in HIV-1 infection.Retrovirology · 2010Review
- The macrophage in HIV-1 infection: from activation to deactivation?Retrovirology · 2010Review
- Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization.PLoS pathogens · 2009Article
- Article
- Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases.Neurotoxicity research · 2005Review
- Expression of CD154 by a simian immunodeficiency virus vector induces only transitory changes in rhesus macaques.Journal of virology · 2005Article
- Fcgamma receptor-mediated suppression of human immunodeficiency virus type 1 replication in primary human macrophages.Journal of virology · 2003Article
- Fractalkine (CX3CL1) and brain inflammation: Implications for HIV-1-associated dementia.Journal of neurovirology · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Mononuclear phagocytes (MP) and T lymphocytes play a pivotal role in the host immune response to human immunodeficiency virus type 1 (HIV-1) infection. Regulation of such immune responses can be mediated, in part, through the interaction of the T-lymphocyte-expressed molecule CD40 ligand (CD40L) with its receptor on MP, CD40. Upregulation of CD40L on CD4+ peripheral blood mononuclear cells during advanced HIV-1 disease has previously been reported. Based on this observation, we studied the influence of CD40L-CD40 interactions on MP effector function and viral regulation in vitro. We monitored productive viral infection, cytokine and beta-chemokine production, and beta-chemokine receptor expression in monocyte-derived macrophages (MDM) after treatment with soluble CD40L. Beginning 1 day after infection and continuing at 3-day intervals, treatment with CD40L inhibited productive HIV-1 infection in MDM in a dose-dependent manner. A concomitant and marked upregulation of beta-chemokines (macrophage inhibitory proteins 1alpha and 1beta and RANTES [regulated upon activation normal T-cell expressed and secreted]) and the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) was observed in HIV-1-infected and CD40L-treated MDM relative to either infected or activated MDM alone. The addition of antibodies to RANTES or TNF-alpha led to a partial reversal of the CD40L-mediated inhibition of HIV-1 infection. Surface expression of CD4 and the beta-chemokine receptor CCR5 was reduced on MDM in response to treatment with CD40L. In addition, treatment of CCR5- and CD4-transfected 293T cells with secretory products from CD40L-stimulated MDM prior to infection with a CCR5-tropic HIV-1 reporter virus led to inhibition of viral entry. In conclusion, we demonstrate that CD40L-mediated inhibition of viral entry coincides with a broad range of MDM immune effector responses and the down-modulation of CCR5 and CD4 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.