ArticleBritish journal of cancer2001
Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 47 citations in OpenAlex.
- Different effects of neuropeptide Y on proliferation of vascular smooth muscle cells via regulation of Geminin.Molecular and cellular biochemistry · 2017Article
- Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach.World journal of gastroenterology · 2012Article
- The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein.British journal of pharmacology · 2011Article
- Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth.World journal of gastroenterology · 2009Article
- Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.Molecular cancer research : MCR · 2009Article
- Erlotinib in the treatment of advanced pancreatic cancer.Biologics : targets & therapy · 2008Article
- Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells.BMC gastroenterology · 2005Article
- Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness.Oncogene · 2004Article
- Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Long-range signal transmission in autocrine relays.Biophysical journal · 2003Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In-vitro and in-vivo studies have shown that autocrine growth factors and receptors are frequently expressed in human malignancies. Few of these studies, however, provide evidence that the identified autocrine pathway is functional. In this study, a functional autocrine growth pathway in pancreatic cancer has been identified using an in-vitro cell culture system. When pancreatic cancer cells were grown without change of medium, proliferation was greater than when either medium was replaced frequently (HPAF, CAPAN-2, PANC-1 or SW1990) or cells were grown in the presence of the EGF receptor tyrosine kinase inhibitor AG1478 or the MEK inhibitor PD098059 (HPAF or CAPAN-2). Activity of extracellular-regulated kinases (ERK) 1 and 2 and c- jun and c- fos mRNA levels were significantly elevated in CAPAN-2 cells cultured continuously in serum-free medium. Collectively, the observations indicate that the EGF receptor and the ERK MAP kinase pathway mediate autocrine signals. In contrast to previous reports, the GRP and IGF-I receptors were shown not to be required for autocrine effects on pancreatic cancer cell proliferation. Autocrine stimulation of the EGF receptor can contribute to sustained mitogenic activity and proliferation of pancreatic cancer cells.
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