ArticleThe Journal of clinical investigation2001
Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cells.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 196 citations in OpenAlex.
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- The Multifaceted Functionality of Plasmacytoid Dendritic Cells in Gastrointestinal Cancers: A Potential Therapeutic Target?Cancers · 2024Review
- An Experimental Model of Neuro-Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells.International journal of molecular sciences · 2022Review
- Quantification of dendritic cell subsets in human thymus tissues of various ages.Immunity & ageing : I & A · 2021Article
- Anatomical structures, cell types and biomarkers of the Human Reference Atlas.Nature cell biology · 2021Review
- Plasmacytoid dendritic cells in the eye.Progress in retinal and eye research · 2021Review
- An overview on the differential diagnostics of tumors of the anterior-superior mediastinum: the pathologist's perspective.Mediastinum (Hong Kong, China) · 2019Review
- Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches.The Journal of experimental medicine · 2017Article
- The development and function of dendritic cell populations and their regulation by miRNAs.Protein & cell · 2017Review
- Expression analysis of surface molecules on human thymic dendritic cells with the 10th HLDA Workshop antibody panel.Clinical & translational immunology · 2015Article
- Conserved and divergent aspects of human T-cell development and migration in humanized mice.Immunology and cell biology · 2015Article
- The multifaceted biology of plasmacytoid dendritic cells.Nature reviews. Immunology · 2015Review
- A discrete population of IFN λ-expressing BDCA3hi dendritic cells is present in human thymus.Immunology and cell biology · 2015Article
- Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines.Nature communications · 2014Article
- Isolation of myeloid dendritic cells and epithelial cells from human thymus.Journal of visualized experiments : JoVE · 2013Article
- Tolerogenic and activatory plasmacytoid dendritic cells in autoimmunity.Frontiers in immunology · 2013Article
- TSLP and immune homeostasis.Allergology international : official journal of the Japanese Society of Allergology · 2012Review
- Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells.Free radical biology & medicine · 2012Article
- Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro.Retrovirology · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three distinct dendritic cell (DC) subsets capable of stimulating allogeneic naive T cells were isolated from human thymus. The most abundant subset was represented by plasmacytoid DCs (pDCs), which secreted high amounts of IFN-alpha upon stimulation with inactivated influenza virus and thus likely correspond to the recently identified peripheral blood natural IFN-alpha/beta-producing cells (IPCs). Like those latter cells, thymic pDCs had distinctive phenotypic features (i.e., Lin(-), HLA-DR(int), IL-3R alpha(hi), CD45RA(hi), CD11c(-), CD13(-), and CD33(lo)) and developed into mature DCs upon culture in IL-3 and CD40L. Of the two other DC subsets, one displayed a phenotype of immature myeloid DCs (imDCs) (HLA-DR(int), CD11c(+), CD13(+), CD33(+)), and the other represented HLA-DR(hi) CD11c(+) mature DCs (mDCs). Since they also expressed DC-LAMP, these mDCs appear to correspond to interdigitating dendritic cells (IDCs). Thymic pDCs, but not myeloid imDCs, strongly expressed lymphoid-specific transcripts such as pre-T alpha, lambda-like, and Spi-B, thereby suggesting a possible lymphoid origin. The detection of Spi-B mRNA, not only upon in vitro maturation of pDCs, but also in freshly purified IDCs, suggests that in vivo pDCs may differentiate into IDCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.