ArticleThe Journal of cell biology2001
The surveillance mechanism of the spindle position checkpoint in yeast.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest.Molecular biology of the cell · 2023Article
- Article
- Prediction of Seizure Recurrence. A Note of Caution.Frontiers in neurology · 2021Article
- Article
- LTE1 promotes exit from mitosis by multiple mechanisms.Molecular biology of the cell · 2016Article
- Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum.The Journal of biological chemistry · 2016Article
- Article
- Article
- Spatial control of microtubule length and lifetime by opposing stabilizing and destabilizing functions of Kinesin-8.Current biology : CB · 2014Article
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.PLoS genetics · 2012Article
- Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4.The Journal of cell biology · 2011Article
- Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae.The Journal of cell biology · 2010Article
- Monitoring spindle orientation: Spindle position checkpoint in charge.Cell division · 2010Article
- The spindle position checkpoint is coordinated by the Elm1 kinase.The Journal of cell biology · 2010Article
- Elm1 kinase activates the spindle position checkpoint kinase Kin4.The Journal of cell biology · 2010Article
- Spindle position is coordinated with cell-cycle progression through establishment of mitotic exit-activating and -inhibitory zones.Molecular cell · 2010Article
- Safeguarding entry into mitosis: the antephase checkpoint.Molecular and cellular biology · 2010Review
- The spindle position checkpoint requires positional feedback from cytoplasmic microtubules.Current biology : CB · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The spindle position checkpoint in Saccharomyces cerevisiae delays mitotic exit until the spindle has moved into the mother-bud neck, ensuring that each daughter cell inherits a nucleus. The small G protein Tem1p is critical in promoting mitotic exit and is concentrated at the spindle pole destined for the bud. The presumed nucleotide exchange factor for Tem1p, Lte1p, is concentrated in the bud. These findings suggested the hypothesis that movement of the spindle pole through the neck allows Tem1p to interact with Lte1p, promoting GTP loading of Tem1p and mitotic exit. However, we report that deletion of LTE1 had little effect on the timing of mitotic exit. We also examined several mutants in which some cells inappropriately exit mitosis even though the spindle is within the mother. In some of these cells, the spindle pole body did not interact with the bud or the neck before mitotic exit. Thus, some alternative mechanism must exist to coordinate mitotic exit with spindle position. In both wild-type and mutant cells, mitotic exit was preceded by loss of cytoplasmic microtubules from the neck. Thus, the spindle position checkpoint may monitor such interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.